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Abstract

Italian

In 20 men, age 35 to 55 years, with cancer of the larynx, activity of N-acetyl-beta-glucosaminidase in peripheral blood lymphocytes was determined cytochemically according to Hayashi's method. Numbers of enzyme-positive cells were counted with regard to the type of cytochemical reaction (granular, granular-diffuse, or diffuse), and to the number of enzyme-positive lysosomal granules within a single cell. In comparison to 20 healthy men, age 20 to 30 years, the following changes were noted in the patients: 1) the decrease of the total count of enzyme-negative lymphocytes; 2) the decrease of the total count of lymphocytes with granular type of reaction; 3) the increase of the counts of lymphocytes with granular-diffuse and diffuse type of reaction. The authors suggest that these changes could be related to the immune reaction of specific tumor antigens.

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References

Astaldi

Lisiewicz

: Lymphocytes - structure, production, functions. Casa Editrice Idelson, Naples, 1971.

Astaldi

Lisiewicz

Cichocki

Burlina

: The lysosomal enzymes in lymphocytes. Part. II. Activated lymphocytes. Acta Vit. Enzymol., 27: 197–206, 1973.

Avilla

J. L.

Convit

: Inhibition of leukocytic lysosomal enzymes by glycosaminoglycans in vitro. Biochem. J., 152: 57–64, 1975.

Bagarry

Favre

Imbert

Jausseran

Meyer

Colonna D'Istria

Serano

: La surveillance immunitaires des cancers O.R.L. J. Franç. Oto-Rhino. Laryngol., 23: 853–859, 1974.

Barman

T. E.

: Enzyme Handbook. Vol. 2, Springer-Verlag, Berlin - Heidelberg, New York, 1968.

Caygill

J. C.

: Inhibition of ram-testis glycosidases by acid muco-polysaccharides. Biochem. J., 98: 9–10, 1966.

Good

R. A.

: Relations between immunity and malignancy. Proc. Natl. Acad. Sci., 69: 1026–1032, 1972.

Hayashi

: The cytologic demonstration of N-acetyl-beta-glucosaminidase employing naphthol AS-BI, N-acetyl-beta-glucosamide and hexasonium pararosaniline. J. Histochem. Cytochem., 13: 26, 1965.

Lewis

M. G.

: Circulating humoral antibodies in cancer. Med. Clin. N. A., 56: 481–499, 1972.

10.

Lisiewicz

: N-acetyl-beta-glucosaminidase in lymphocytes of patients with Hodgkin's disease, plasma cell myeloma, and primary polycythemia. Rev. Roum. Med. Int., 14: 285–289, 1976.

11.

Lisiewicz

Bryniak

Sroczynska

: N-acetyl-beta-glucosaminidase of lymphocytes in the premature infant with special reference to the fetal development of the lysosomal apparatus. Acta Paediatr. Scand., 65: 167–170, 1976.

12.

Lisiewicz

Bryniak

Seibert

: Enzymatic equipment of lymphocyte lysosomes in the premature or term infants and in the adults. Rev. Roum. Med. Int., 13: 209–213, 1975.

13.

Lisiewicz

Sowa

: Te lysosomal enzymes of lymphocytes in the blood of patients with viral hepatitis. Rev. Esp. Oncol., 21: 307–318, 1974.

14.

Pearse

A. G. E.

: Histochemistry, theoretical and applied. Vol. 2, 3rd Edition. Churchill, Livingstone, 1972.

15.

Platt

Loeffler

: Cytochemischer Nachweis der beta-acetylglucosaminidase in menschlichen Blut und Knochenmarkzellen. Klin. Wochenschr., 46: 617–618, 1968.

16.

Reed

C. F.

Bennet

J. M.

: N-acetyl-beta-glucosaminidase activity in normal and manignant leukocytes. J. Histochem. Cytochem., 23: 752–757, 1975.

17.

Robinson

Stirling

: N-acetyl-beta-glucosaminidase in human spleen. Biochem. J., 107: 321–327, 1968.

18.

Sessions

R. B.

Goepfert

Adam

Rawls

: Herpesvirus and Epstein-Barr virus antibodies and carcinoma of the intrinsic larynx. Arch. Otolaryngol., 99: 261–263, 1974.

19.

Urasinski

Krygier-Stojalowska

Mozolewski

Koselnik-Glugla

Wasilewska

: Blastic transformation of peripheral blood lymphocytes in patients with cancer of the larynx. (In Polish). Pat. Pol., 26: 11–13, 1975.

N-Acetyl-Beta-Glucosaminidase of Peripheral Blood Lymphocytes in Patients with Cancer of the Larynx

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