Herpes Simplex Virus Tumor-Associated Antigens in Cancer Patients

Abstract

Italian

Data are reported on the HSV nonstructural antigens detected in GPK and RK cells after infection with the same strain of virus. Both the HSV types 1 and 2 NV antigens consist of more than one component for which the immunized guinea pigs produce distinct antibodies. It was possible to separate by PAGE, HSV-induced markers not only from cells undergoing lytic infection by the virus but also from viable cells from squamous cell carcinoma of the head and neck and the urogenital tract. These fractions were tested with sera from cancer patients, and the percentages of their CF reactivity are reported. The specificity of the antibody to the antigen from the cancer cells was less high than that of the antibody to the antigen from HSV-infected cells. It is suggested that the use of these PAGE separate antigens would eliminate the need for removal of the virion antibody from the cancer sera prior to testing them for the NV-specific antibody.

Get full access to this article

View all access options for this article.

References

Aurelian

Schuman

Marcus

R. L.

Davis

H. J.

: Antibody to HSV-2-induced tumor specific antigen in sera from patients with cervical carcinoma. Science: 181: 161–164, 1973.

Hollinshead

A. C.

Chretien

P. B.

Lee

Tarpley

J. L.

Kerney

S. E.

Silverman

N. A.

Alexander

J. C.

: In vivo and in vitro measurements of the relationship of human squamous carcinomas to herpes simplex virus tumor-associated antigens. Cancer Res., 36: 557–564, 1976.

Hollinshead

A. C.

Chretien

P. B.

Tarpley

J. L.

: Studies of the nature of HSV-TAA (NVA) induced by herpes simplex virus type 1 and further analysis of the relationship to squamous carcinoma of the head and neck region. pp. 307–311. In: Oncogenesis and Herpes-viruses II (Part. II), de Thè

Epstein

M. A.

zur Hausen

(eds.), International Agency for Research on Cancer, IARC Scientific Publications No. 11, Lyon, 1975.

Hollinshead

A. C.

Lee

Chretien

P. B.

Tarpley

J. L.

Rawls

W. E.

Adam

A. C.

: Antibodies to herpesvirus nonvirion antigens in squamous carcinomas. Science, 182: 713–715, 1973.

Hollinshead

A. C.

Stewart

T. H. M.

Herberman

R. B.

: Delayed hypersensitivity reactions to soluble membrane antigens of human malignant lung cells. J. Nat. Cancer Inst., 52: 327–338, 1973.

Hollinshead

A. C.

Tarro

: Soluble membrane antigens of lip and cervical carcinomas: reactivity with antibody for herpesvirus nonvirion antigens. Science, 179: 698–700, 1973.

Hollinshead

A. C.

Tarro

Chretien

P. B.

Rawls

W. E.

: Characterization of herpesvirus nonvirion antigens: relation to squamous cell carcinomas. pp. 301–317. In: Viral Immunodiagnosis, Kurstak

Morisset

(eds.), New York: Academic Press Inc., 1974.

Hollinshead

A. C.

Tarro

Foster

W. A.

Seigel

L. J.

Jaffurs

: Studies of tumor-specific and herpesvirus nonvirion antigens. Cancer Res., 34: 1122–1125, 1974.

Honess

R. W.

Roizman

: Protein specified by herpes simplex virus. Identification and relative molar rates of synthesis of structural and non structural herpes virus polypeptides in the infected cells. J. Virol., 12: 1347–1365, 1973.

10.

Lehner

Wilton

J. M. A.

Shillitoe

Ivanyi

: Cell-mediated immunity and antibodies to herpesvirus hominis type 1 in oral leukoplakia and carcinoma. Br. J. Cancer, 27: 351, 1973.

11.

Nahmias

A. J.

Del Buono

Ibrahim

: Antigenic relationship between herpes simplex viruses, human cervical cancer and HSV-associated hamster tumors. pp. 309–313. In: Oncogenesis and Herpes-viruses II (part I), de Thè

Epstein

M. A.

zur Hausen

(eds.), International Agency for Research on Cancer, IARC Scientific Publications, No. 11, Lyon, 1975.

12.

Sabin

A. B.

Tarro

: Herpes simplex and herpes genitalis viruses in etiology of some human cancers. Proc. Nat. Acad. Sci., 70: 3225–3229, 1973.

13.

Tarro

: Analysis and description of procedures used in the study of the relationship of herpes simplex virus « non-virion » antigens to certain cancers, pp. 291–297. In: Oncogenesis and Herpes-viruses II (Part II), de Thè

Epstein

M. A.

zur Hausen

(eds.), International Agency for Research on Cancer, IARC Scientific Publications, No. 11, Lyon, 1975.

14.

Tarro

Sabin

A. B.

: Virus-specific, labile, nonvirion antigens in herpesvirus-infected cells. Proc. Nat. Acad. Sci., 65: 753–760, 1970.

15.

Tarro

Sabin

A. B.

: Nonvirion antigens produced by herpes simplex viruses 1 and 2. Proc. Nat. Acad. Sci., 70: 1032–1036, 1973.