C3HeB/Fe male and female mice, ingesting 10 ppm of the pesticides dieldrin or aldrin in the diet, developed highly significant incidences of carcinomas of the liver. The carcinomas varied from well differentiated to poorly differentiated and undifferentiated and were capable of metastasis.
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References
1.
DavisK. J.: Pathology report on mice fed aldrin, dieldrin, heptachlor or heptachlor epoxide for two years (prepared as a memorandum to A. J. Lehman, Food and Drug Administration, Washington D.C., on July 19, 1965).
2.
DavisK. J.: Histologic diagnoses of lesions noted in mice fed DDT or methoxychlor for two years (prepared as a memorandum to W. Hansen, Food and Drug Administration, Washington, D.C., on January 30, 1969).
3.
DavisK. J.FitzhughO. G.: Tumorigenic potential of aldrin and dieldrin in mice. Tox. Appl. Pharmacol., 4: 187–189, 1962.
4.
GrossM. A.: Testimony at hearings in Aldrin/Dieldrin (E.P.A. and Environmental Defense Fund vs Shell) August, 1974.
5.
JonesG.ButlerW. H.: Morphology of spontaneous and induced neoplasia. In: Mice Hepatic Neoplasia.ButlerW. H.NewberneP.M. (eds.), Elsevier Scientific Publishing Co., Amsterdam, 1975.
6.
Mac DonaldW. E.AndersonW. A. D.BevilacquaM.BlumE.DeichmanW. B.: The tumorigenicity of dieldrin in the Swiss-Webster mouse (Preliminary report prepared for publication, September, 1972).
7.
OpieE. L.: The pathogenesis of tumors of the liver produced by butter yellow. J. Exp. Med., 80: 231–246, 1944.
8.
ReuberM. D.: Development of preneoplastic and neoplastic lesions of the liver in male rats given 0.025 percent N-2-fluorenyldiacetamide. J. Nat. Cancer Inst., 34: 697–724, 1965.
9.
ReuberM. D.: Poorly differentiated cholangiocarcinomas occurring « spontaneously » in C3H and C3H x Y hybrid mice. J. Nat. Cancer Inst., 38: 901–907, 1967.
10.
ReuberM. D.: Testimony at hearings in Aldrin/Dieldrin (E.P.A. and Environmental Defense Fund vs Shell) December, 1973.
11.
ReuberM. D.: Criteria for tumor diagnosis and classification of malignancy. pp. 71–73. In: Carcinogenesis Testing of Chemicals.GoldbergL. (ed.), CRC Press, Inc., Cleveland, Ohio, 1974.
ReuberM. D.: Histopathology of transplantable carcinomas and sarcomas of the liver in mice ingesting dieldrin or aldrin. Bull. Soc. Pharmacol. Environ. Pathol., 4: 1–16, 1976.
14.
ReuberM. D.: Histogenesis of hyperplasia, hyperplastic nodules and carcinomas of the liver arising around central veins in mice ingesting chlorinated hydrocarbons. Path. Microbiol., 43: 287–298, 1975.
15.
ReuberM. D.GloverE. L.: Hyperplastic and early neoplastic lesions of the liver in Buffalo strain rats of varying ages given subcutaneous carbon tetrachloride. J. Nat. Cancer Inst., 38: 891–899, 1967.
16.
SongJ.HarvilleW. E.: Carcinogenicity of aldrin and dieldrin on mouse and rat liver. Fed. Proc., 23: 336, 1964.
17.
ThorpeE.: Testimony at hearings in Aldrin/Dieldrin (E.P.A. and Environmental Defense Fund vs Shell) August, 1974.
18.
ThorpeE.WalkerA. I. T.: The toxicology of dieldrin (HEOD). II. Comparative long-term oral toxicity studies in mice with dieldrin, DDT, phenobarbitone, β-BHC and γ-BHC. Fd. Cosmet. Toxicol., 11: 433–442, 1973.
19.
TurosovV. S.DayN.TomatisL.GatiE.CharlesR. T.: Tumors in CF-1 mice exposed for six consecutive generations to DDT. I. Nat. Cancer Inst., 51: 983–997, 1973.
20.
TurosovV. S.DeringerM. K.DunnT. B.StewartH. L.: Malignant mouse–liver tumors resembling human hepatoblastomas. J. Nat. Cancer Inst., 51: 1689–1695, 1973.
21.
VlahakisG.HestonW. E.: Spontaneous cholangiomas in strain C3H-A x Y-fB mice and their hybrids. J. Nat. Cancer Inst., 46: 677–683, 1971.
22.
VlahakisG.ReuberM. D.: Carcinomas of the liver in C3H-A x Y-fB mice ingesting DDT. (In preparation, 1976).
23.
WalkerA. I. T.ThorpeE.StevensonD. E.: The toxicology of dieldrin (HEOD). 1. Long-term toxicity studies in mice. Fd. Cosmet. Toxicol., 11: 415–432, 1972.
