A case of Grawitz tumor with diffuse sarcomatous-like pattern is reported. This feature is regarded as the anaplastic evolution of a carcinoma, lacking glycogen and rich in lipids. Since this histochemical specificity is maintained in the sarcomatous-like fields, the searching for lipids and serial sectioning examination of the neoplasia is mandatory unless ultrastructural analysis is available. This histological approach is useful when a pathologist, dealing with a lesion suggestive of soft tissue tumor, has to diagnose or exclude an epithelial origin for the neoplasia. Malignancy of the sarcomatous-like areas is shown by the malignant nuclear B and BC structures that exclude the possibility of stromal desmoplasia.
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