A Specific Spontaneous Leucocyte Cycle in Chronic Myelogenous Leukemia

Abstract

Cyclic leukocytosis has been previously described in patients with chronic myeloid leukemia (CML). The purpose of this report is to call attention to the possibility of a specific long-term cycle of approximately two months in CML, on the basis of the reported patients studied prospectively with no treatment and to describe an additional case with similar changes. Kinetic studies suggest that the leucocyte oscillation observed would reflect variation in cell production. Implications of the findings with regard to pathogenesis and therapy of the disease are discussed. A long-term cycle of the neutrophil count, showing a period of approximately two months, was also found in eight children with acute myelogenous leukemia (AML) in remission, analyzed retrospectively.