Hydrazine Sulphate (H.S.) even at low doses, equivalent to those administered with isoniazid in man, induced pulmonary tumours in the mouse, more actively in female BALB/c, CBA and C3Hb intact virgin mice. Endogenous ovarian stimulation (provoked by breeding, forced breeding and pseudo-pregnancy) increased the morphological malignancy and the carcinogenic index of these tumours in BALB/c and C3Hb mice. H.S. also induced mammary carcinomas in 38 % of forced bred BALB/c mice. Because of their extensive medical, industrial, agricultural and aero-spatial use, H. S. and hydrazine derivatives should be investigated. Several hydrazine derivatives are carcinogenic in mice, rats and hamsters.
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References
1.
BiancifioriC.: Influenza di un fattore ormonico nella cancerogenesi polmonare da idrazina.Lavori Ist. Anat. Univ. Perugia, 29: 29–41, 1969.
2.
BiancifioriC.: Tumori polmonari ed epatici da idrazina solfato a dosi ridotte in topi BALB/c/Cb/Se.Lavori Ist. Anat. Univ. Perugia, 30: 89–99, 1970.
3.
BiancifioriC.: Tumori polmonari da idrazina solfato a dosi ridotte in topi BALB/c/Cb/Se gonadectomizzati.Lavori Ist. Anat. Univ. Perugia,30, 113–119, 1970.
4.
BiancifioriC.: Ovarian Influence on Pulmonary Carcinogenesis by Hydrazine Sulfate in BALB/c/Cb/Se mice.J. Nat. Cancer Inst., 45: 965–970, 1970.
5.
BiancifioriC.: Influenza degli ormoni ovarici nella cancerogenesi polmonare da idrazina solfato in topi C3Hb/Cb/Se.Lavori Ist. Anat. Univ. Perugia, 31: 5–17, 1971.
6.
BiancifioriC.: Tumori polmonari e mammari da idrazina solfato in topi BALB/c/Cb/Se gestanti forzate e pseudogravide.Lavori Ist. Anat. Univ. Perugia, 31: 79–90, 1971.
7.
BiancifioriC., BonserG. M., CascheraF.: The influence of pseudopregnancy on the induction of mammary tumours by Methylcholanthrene in mice of BALB/c strain.Brit. J. Cancer, 13: 622–668, 1959.
8.
BiancifioriC., BonserG. M., CascheraF.: Chemically induced mammary tumours following unilateral excission of the nipples in pseudopregnant and lactating BALB/c mice.Brit. J. Cancer, 16: 232–237, 1962.
9.
BiancifioriC., BucciarelliE., ClaysonD. B., SantilliF. E.: Induction of hepatomas in CBA/Cb/Se mice by hydrazine sulphate and the lack of effect of croton oil on tumour induction in BALB/c/Cb/Se mice.Brit. J. Cancer, 18: 543–550, 1964.
10.
BiancifioriC., RibacchiR.: Pulmonary tumours in mice induced by oral administration of isoniazid and its metabolites.Nature, 194: 488–489, 1962.
11.
BiancifioriC., RibacchiR.: The induction of pulmonary tumors in BALB/c mice by oral administration of isoniazid. In: The Morphological Precursors of Cancer. pp. 635–642. SeveriL., Division of Cancer Research, Perugia, 1962.
12.
ClaysonD. B., BiancifioriC., MiliaU., Giornelli - SantilliF. E.: The induction of pulmonary tumours in BALB/c/Cb/Se mice by Hydrazine derivatives. In: Lung Tumours in Animals. pp. 869–880, SeveriL., Division of Cancer Research, Perugia, 1965.
13.
JuchauM. R., HoritaA.: Metabolism of Hydrazine Derivatives of Pharmacologic interest.Drug. Metab. Revs., 1: 71–100, 1972.
14.
KellyM. G., O'GaraR. W., KumudiniG., YanceyS. T., OliverioV. T.: Carcinogenic activity of a new antitumour agent, N-Isopropyl-alfa-(2-Methylhydrazino)-p-Toluamide Hydrochloride (NSC 77-213).Cancer Chem. Res., 39: 77–80, 1964.
15.
MartinM. S., MartinF., MichielsR., BastienH., JustraboE., BordesM., ViryB.: An Experimental Model for Cancer of the Colon and Rectum. Intestinal Carcinoma induced in the rat by 1,2 Dimethylhydrazine.Digestion, 8: 22–43, 1973.
16.
SeveriL.: Isoniazid.Cancer Bull.,16: 79, 1964.
17.
SeveriL., BiancifioriC.: Isoniazid and allied compounds as related to lung tumours in animals.Growth, 30: 367–382, 1966.
18.
SeveriL., BiancifioriC.: Hepatic carcinogenesis in CBA/Cb/Se mice and Cb/Se rats by isonicotinic acid hydrazide and hydrazine sulfate.J. Nat. Cancer Inst., 41: 331–349, 1968.
19.
TothB.: Tumorigenesis studies with 1,2 Dimethylhydrazine Dihydrochloride, Hydrazine sulfate and isonicotinic acid in Golden hamsters.Cancer Res., 32: 804–807, 1972.
20.
TothB.: Benzoylhydrazide carcinogenesis in lung and lymphoreticular tissue of Swiss mice.Europ. J. Cancer, 8: 341–346, 1972.
21.
TothB., ShimizuH.: Methylhydrazine Tumorigenesis in Syrian Golden Hamsters and the Morphology of Malignant Histiocytomas.Cancer Res., 33: 2744–2753, 1973.
22.
TothB., WilsonR. D.: Blood vessel tumorigenesis by 1,2 Dimethylhydrazine Dihydrochloride (symmetrical).Gross, Light and electron microscope description. Amer. J. Path., 64: 585–600, 1971.
