Investigations were conducted on the RNA/protein ratio and in vitro functional activity of the large pool of 80 s ribosomes and their subunits isolated from some mouse tumors. No differences in the capacity of these ribosomes for polyU-directed polyphenylalanine synthesis were observed. On the other hand, the large subunit of Ehrlich and Sarcoma 180 tumors was found to have a different RNA/protein ratio (corresponding to a loss of about 5 % of its protein content) from the 60 s subunit of mouse liver.
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