The case of a 65-year old man with chronic lymphocytic leukemia associated with reticulum cell sarcoma (histiocytic diffuse lymphoma) is reported. The patient was not pretreated with radiotherapy and/or chemotherapy. The simultaneous diagnosis was made when the patient was first hospitalized and not post-mortem. The coexistence of the two types of association (CLL+RSA and CLL+Hodgkin's disease, known as Richter's syndrome) is discussed.
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