Report of a topographical study on 12 cases of breast cancer designed to establish whether all the areas of a given tumor had the same sex chromatin, this being essential for the determination of tumoral sex to be a valid therapeutic guide. The results show that, although there may be variations in the number of nuclei with sex chromatin, the variations are not so great as to alter the tumoral sex in a given tumor. The determination of tumoral sex on a single tumor fragment is therefore valid.
Get full access to this article
View all access options for this article.
References
1.
BaradnayG., and ManusZ. B.: Sex chromatin studies in female mammary carcinoma.Bull. Soc. int. Chir., 23: 17–23, 1964.
2.
BarrM. L., and BertramE. G.: Morphological distinction between neurones of the male and female and the behavior of the nucleolar satellite during accelerated nucleoprotein synthesis.Nature, 163: 676–677, 1949.
3.
BlumelG., TurcieG., RegeleH., und VogoisH.: Teil Oertliches Rezidin und Zellkern-morphologisches Tumorgeschlechit.Wien. klin. Wschr., 75: 41–43, 1963.
4.
EhlersP. N., und HienzH. A.: Zellkernmorphologisches geschlecht und hormonelle Beeinflubbarkeit des mamma carcindomas.Langenbecks Arch. Klin. Chir., 288: 485–498, 1958.
5.
EhlersP. N., HienzH., HochbergC., and NuriM.: Further studies on the practical conclusions of investigation for the morphology of the cell nucleons in mammary carcinoma.Chirurg., 35: 271–272, 1964.
6.
GroppV. H., WolfU., und PeraF.: Sex chromatin und chromosomenstatus Bein mammkarzinon.Dtsch. med. Wschr., 15: 637–642, 1965.
7.
GrossF., MahringerW., TrebinH., und BohleA.: Zur Bedeutung der Barrschen Zellkernkörper bein Brustkrebs der Frau.Dtsch. med. Wschr., 89: 1215–1217, 1964.
8.
HunterW. F., and LennoxB.: Sex of teratoma.Preliminary communication. Lancet, 2: 633–634, 1954.
9.
KallembergerA.: Die Beurteilung der Mammakarzinome nach dem Gehalt an Kermen mit Geschltochromatin und Heterochromatin.Schweiz. med. Wschr., 76: 873–874, 1964.
10.
KimelV. M.: Clinical cytological correlations of mammary carcinoma based upon sex-chromatin counts, a preliminary study.Cancer, 10: 922–927, 1957.
11.
ManciniA. M.: Geschlechtsbestimmung on Zellkern zur Klarung der Pathogenese der teratona und Hadengeschwulste.Z. Krebsforsch., 61: 376–380, 1956.
12.
MooreK. L., and BarrM. L.: Nucleolar morphology according to sex in human tissues.Acta Anat., 21: 197–208, 1954.
13.
MostofiF. K., TheissE. A., and AshleyD. J. B.: Tumor of specialized gonadal strona in human male patients; androblastoma, sertole cell tumor, granulosa-theca cell, tumor of testis and gonadal strona tumor.Cancer, 12: 944–957, 1959.
14.
MyersL. M.: Nuclear sex of teratomas. In: Simposium on nuclear sex.SmithD. R., and DavidsonW. M. Eds. p. 143–159, W. Eineman Ltd., England, 1958.
15.
ParkW. W.: Occurrence of sex chromatin in chorionepiteliomas and hydatiform moles.J. Path. Bact., 74: 197–206, 1957.
16.
RegeleH., KaufmanF., and WaslH.: The problem of sex chromatin in tumors.Krebsarzt., 19: 11–17, 1964.
17.
RivièreM.: Sur la presénce de la « Chromatine sexuelle » dans les tumeurs humaines et en particulier dans les neoplasmes de glandes germinatives.Bull. Ass. franç. Cancer, 43: 35–51, 1956.
18.
RuprechitG., und MarzoliP. C.: Des zell Kernmorphologische Geschilecht von tumoren Endokrin Beeinflubarer Organe.Bruns Beitr. klin. Chir., 202: 242–253, 1961.
19.
ShirleyR. L.: The nuclear sex of breast cancer.S.G.O., 125: 737–740, 1967.
20.
TavaresA. S.: On sex of cancer and teratoma cells.Lancet, 1: 948–949, 1955.
21.
TavaresA. S.: Tumores e sexo núclear.Médico (Porto), 9: 8–32, 1958.
22.
TheissE. A., DavidJ. B., AshleyM. D., and MostofiF. K.: Nuclear sex of testicular tumors and some related ovarian and extragonadal neoplasms.Cancer, 13: 2, 1960.
23.
WackerB., and MilesC. P.: Sex chromatin incidence and prognosis and breast cancer.Cancer, 19: 1651–1674, 1966.
