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Abstract

Italian

With the purpose of investigating the histogenesis of malignant skin melanoma, 194 cases were studied in which the tumor was fully represented in a microscopic slide and the behavior of melanoblasts could be observed above the tumor, at its edges and on both sides of it. Intense proliferation of melanoblasts of the epidermis, accompanying the migration (« Abtropfung ») of the cells into the derma, was found in 82 out of 194 operated patients with malignant melanomas. Such neoplasms usually had the appearance of a spot or infiltrate and were most frequently localized on the lower extremities. The tumors of this kind were defined as epidermo-dermal malignant melanomas. In 112 cases the tumors were of another pattern. Junctional melanoblasts did not participate in their formation; they developed from cells located only in the derma and originating from cells of intradermal nevi. They had typical growth in the form of a pedunculated nodule or of a nodule on a broad base; most frequently they were localized on the trunk. Tumors of this kind were defined as intradermal malignant melanomas.

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References

Allen

A. C.

: A reorientation of the histogenesis and clinical significance of cutaneous nevi and melanomas. Cancer, 2: 28–56, 1949.

Allen

A. C.

, and Spitz

: Histogenesis and clinicopathological correlation of nevi and malignant melanomas. Arch. Derm. Syph., 69: 150–171, 1954.

Cox

A. J.

, Walton

R. G.

, and Calif

P. A.

: The induction of junctional changes in pigmented nevi. Arch. Path., 79: 5: 428–434, 1965.

Ghadially

F. N.

: Some etiological factors in the production of malignant melanoma. Experientia, 16, 7: 312–313, 1960.

Ghadially

F. N.

, and Illma

: The histogenesis of experimentally produced melanotic tumours in the Chinese hamster. Brit. J. Cancer, 17: 727–730, 1963.

Ghadially

F. N.

: Trauma and melanoma production. Nature, 211: 1199, 1966.

Kimmig

, und Rohde

: Gewebekultur mit unbestrahltem und bestrahtem Melanomgewebe. Dermat. Wochenschr., 148, 39: 327–328, 1963.

Lewis

M. G.

, and Kirgabwine

J. W.

: Aspects of behavior and natural history of malignant melanoma in Uganda. Cancer, 21, 5: 876–888, 1968.

Masson

: My conception of cellular nevi. Cancer, 4: 9–38, 1951.

10.

Mishima

: Melanocytic and nevocytic malignant melanomas. Cellular and subcellular differentiation. Cancer, 20, 5: 632–649, 1967.

11.

Nakai

, and Rappaport

: A study of the histogenesis of experimental tumors resembling cellular blue nevi: The evidence in support of their neurogenic origin. Amer. J. Path., 43: 175–198, 1963.

12.

Natanson

I. C.

, Hail

T. C.

, and Farber

: Biological aspects of human malignant melanoma. Cancer, 20, 5: 650–655, 1967.

13.

Ocun

M. R.

, and Bauman

: Malignant melanoma arising from intradermal nevus. Arch. Derm., Chicago, 92: 69–72, 1965.

14.

Olsen

: The malignant melanoma of the skin. Stockholm, 1966.

15.

Reed

W. B.

, Becker

, and Nickel

W. R.

: Giant pigmented nevi, melanoma and leptomeningeal melanocytosis.

16.

Ricci

S. B.

, e Guarino

: Studio istologico e clinico di 136 casi di melanoblastoma. Tumori, 50, 3: 201–205, 1964.

17.

Schuhmachers-Brendler

: Contribution to the clinical aspects and histology of nevocellular nevi and at juvenile melanoma. I. On the genesis, manifestation and histology of nevicellular nevi. Arch. Klin. exp. Derm., 217: 577–599, 1963.

18.

Shapiro

, and Bodian

E. L.

: Malignant melanoma in the form of pedunculated papules. Arch. Derm., Chicago, 99, 1: 49–56, 1969.

19.

Staricco

R. S.

, Pinkus

, and Fornaugh

R. P.

: Human melanocytes in tissue culture. J. invest. Derm., 28, 1: 15–32, 1957.

20.

Staricco

R. S.

, and Pinkus

: Quantitative and qualitative data on the pigment cells of adult human epidermis. J. invest. Derm., 28, 1: 33–45, 1957.

21.

Szabo

: Quantitative histological investigations on melanocyte system of the human epidermis. Pigment Cell Biol., N. Y., Acad. Press, 99–125, 1959.

22.

Szalay

: On the problem of malignant degeneration of pigmented nevi. Acta morph. Acad. Sci. Hung., 12: 149–161, 1963.

23.

Trapl

, Palecek

, and Ebel

: Origin and development of skin melanoblastoma on the basis of 300 cases. Acta derm. vener., 44, 5: 377–380, 1964.

24.

Willis

R. A.

: Pathology of tumors. p. 443, Butterworth and Co. Ed., London, 1950.

25.

Winkler

: Zur Histologie der malignen Melanoma. Dtsch. Gesundh. Wes., 12, 23: 705–708, 1957.

26.

Woringer

: Zone jonctionnelle et interactions naevo-malpighennes dans les tumeurs melaniques. Ann. Derm. Syph., Paris, 86, 4: 361–371, 1959.

HISTOGENETICAL PECULIARITIES OF MALIGNANT SKIN MELANOMAS

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