A study on 229 cases of oral cavity tumors with the invasion of the mandible observed at the National Cancer Institute, Milan, and at the Institute of Radiology, University of Milan, from 1928 to 1967 is reported. Of these cases 73 were subjected to radical surgery, 15 were conservatively operated, 46 had radiant therapy, and 95 received no cure at all for tumor extension. Radical surgery, that is the surgical removal of the hemimandible invaded by the tumor, associated with the ablation of homolateral laterocervical lymph node chains, is the most rational measure and can yield excellent results; for radical surgery the median survival rate is of 2 years; the relative survival rate is of 49%, 5 years after the operation. Conservative surgery and radiotheraphy are secondary measures which, in principle, should be carried out only in case of technical contra-indications or patients refusal of radical surgery.
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