A series of 70 patients with advanced incurable neoplasms, received a combined treatment with vinblastine (VLB) and vincristine (VCR). VLB was given at a dose of 7.5 to 10 mg and VCR at a dose of 0.75 to 1 mg. The two agents were administered intravenously at weekly intervals. Good remissions were obtained in patients with lymphoma and with mycosis fungoides. The best results were obtained in the cases of Hodgkin's disease. It is of interest that the combined treatment was effective in cases which had already become resistant or poorly responsive to various chemical agents including, in a few cases, the vinca alkaloids given separately.
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References
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CardinaliG., and CardinaliG.: Experimental studies on the combined use of Vinblastine and Vincristine.Chemioterapia, 12: 226–229, 1967.
2.
CardinaliG., and CardinaliG.: Preliminary studies on the effect of the combined use of Vinblastine and Vincristine in the treatment of tumors.Proc. 5th Int. Congres. Chemother. B10/21 p. 277–279, 1967.
