Respiration and glycolysis (anaerobic and aerobic) in homogenates from seven cases of epidermal carcinoma and one case of adenocarcinoma of the uterine cervix were investigated. The malignant tissues were characterized by a high anaerobic and aerobic glycolysis and by a low level of respiration. The numerical indexes between anaerobic and aerobic glycolysis and respiration were 5 - 6.9 and 5.1 - 9.2 respectively, showing a low Pasteur effect. The results show that the competition between respiration and glycolysis ends up at full advantage of glycolysis.
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References
1.
AisenbergA. C.: The glycolysis and respiration of tumors.Academic Press, New York, 1961.
2.
BurkD., AlgireG. H., HesselbachM. L., FischerC. E., and LegallisF. Y.: In: Biology of melanomas. (MinerR. W., and GordonM. Eds.). Pag. 437, New York Academy of Sciences, 1948.
3.
de RoetthH.: Chemical characteristics and varying degrees of malignancy in tumors of the human ovary.I. Oxygen consumption and lactic acid production. Cancer Res., 17: 833–840, 1957.
4.
EschbachW.: Atmung und Glycolyse des Portioepithels zwei Jahre nach Abtragung eines sogenannten Oberflächenkarzinoms.Zeitschr. Geburtsch. Gynäk., 148: 1–4, 1957.
5.
HawkP. B., OserB. L., and SummersonW. H.: Practical physiological chemistry. Pag. 874, McGraw-Hill Book Co., New York, 1954.
6.
KrebsH. A.: Body size and tissue respiration.Biochem. Biophys. Acta, 4: 249–269, 1950.
7.
PhillipsH. J., and McCarthyH. L.: Oxygen uptake and lactate formation of HeLa cells.Proc. Soc. Exp. Biol. & Med., 93: 573–576, 1956.
8.
WarburgO.: Metabolism of tumors.Arnold Constable, London, 1930.
9.
WeinhouseS.: On respiratory impairment in cancer cells.Science, 124: 267–269, 1956.
