Sono stati studiati al microscopio elettronico 34 tumori mammari indotti con impianto ipofisario isologo in topi (O20xIF)F1, (C57BLxCBA)F1 e CBA. In nessun tumore sono state rinvenute particelle « B » o precursori, ma in 7 tumori dei tre ceppi studiati sono state osservate particelle intracitoplasmatiche, esclusivamente all'interno delle cisterne del reticolo endoplasmico ruvido. Queste particelle di 70–80 mμ non mostrano un nucleoide denso ed hanno una struttura anulare in cui si possono talvolta notare tre strati opachi. Esse sono simili a quelle osservate in altri tumori non mammari del topo e, sporadicamente, nel tessuto mammario dei topi BALB/c.
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References
1.
AdamsW. R., and PrinceA.M.: An electron microscope study of the morphology and distribution of the intracytoplasmic « virus-like » particles of Ehrlich ascites tumor cells.J. Biophys. Biochem. Cytol., 3: 161–170, 1957.
2.
AmanoS., and IchikawaY.: Electron microscopical aspects of developing modes of the cancer virus and the problem of « pseudovirus particles ».Acta Path. Jap., 9: 455–479, 1959.
3.
BernhardW.: The detection and study of tumor viruses with the electron microscope.Cancer Res., 20: 712–727, 1960.
4.
BootL. M., MühlbockO., RöpckeG., and van Ebbenhorst TengbergenW.: Further investigations on induction of mammary cancer in mice by isografts of hypophyseal tissue.Cancer Res., 22: 713–727, 1962.
5.
DaltonA. J., and FelixM. D.: The electron microscopy of normal and malignant cells.Ann. N. Y. Acad. Sci., 63: 1117–1140, 1956.
6.
DaltonA. J., PotterM., and MerwinR. M.: Some ultrastructural characteristics of a series of primary and transplanted plasma-cell tumors of the mouse.J. Nat. Cancer Inst., 26: 1221–1267, 1961.
7.
DmochowskiL., GreyC. E., PadgettF., and SykesJ. A.: Studies on the structure of the mammary tumor-inducing virus (Bittner) and of leukemia virus (Gross). In: Viruses, nucleic acids and cancer, pag. 85–121; Williams & Wilkins Co., Baltimore, 1963.
8.
FeldmanD. G.: Origin and distribution of virus-like particles associated with mammary tumors in DBA strain mice. II. Virus-like particles in the blood and organs.J. Nat. Cancer Inst., 30: 503–515, 1963.
9.
GranboulanN., RivièreM. R., et BernhardW.: Présence de particules d'aspect viral dans un sarcome greffable de la souris provoqué par le méthylcholanthrène.Bull. Ass. Franc. Cancer, 47: 291–307, 1960.
10.
HaguenauF., and HollmannK. H.: Présence de particules d'aspect viral dans les thymomes transplantables des souris DBA/2. Etude ultra-morphologique de leur formation.C. R. Acad. Sci., 256: 3541–3544, 1963.
11.
HairstoneM. A., LyonsM. J., and MooreD. H.: Morphological distinction of type B virus particles in mammary tumors of strain A mice.Virology, 23: 294–297, 1964.
12.
HairstoneM. A., SheffieldJ. B., and MooreD. H.: Study of B particles in the mammary tumors of different mouse strains.J. Nat Cancer Inst., 33: 825–836, 1964.
13.
Mc Gee-RussellS. M., VizosoA. D., and SandersF. K.: Observations on virus ascites-cell systems. Proc. 3rd European Regional Conference on Electron Microscopy, pag. 367–368, Publishing House of the Czechoslovak Academy of Sciences, Prague, 1964.
MooreD. H., and LyonsM. J.: Studies of replication and properties of the Bittner virus. In: Viruses, nucleic acids and cancer, pag. 224–242, Williams & Wilkins Co., Baltimore, 1963.
16.
MühlbockO., and BootL. M.: Induction of mammary cancer in mice without the mammary tumor agent by isografts of hypophyses.Cancer Res., 19: 402–412, 1959.
17.
PitelkaD. R., BernH. A., NandiS., and De OmeK. B.: On the significance of virus-like particles in mammary tissues of C3Hf mice.J. Nat. Cancer Inst., 33: 867–885, 1964.
18.
PitelkaD. R., De OmeK. B., and BernH. A.: Virus-like particles in precancerous hyperplastic mammary tissues of C3H and C3Hf mice.J. Nat. Cancer Inst., 25: 753–777, 1960.
