Five mg of benzo[a]pyrene and 500 mg of epsilon-aminocaproic acid were injected subcutaneously three times, at the same site and at the same time, to 15 Wistar rats, while a control group was given benzpyrene alone. Subcutaneous sarcomas developed in all animals of both groups, but in the animals treated with both chemicals the latent period and the survival time was significantly shorter than in the control group, and, at the death of the animals, the weight of the tumors was considerably greater.
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References
1.
AmatiA., LibroV., e MarianiL.: Attività di inibitori della proteolisi sullo shock anafilattico della cavia.Boll. Soc. It. Biol. Sper., 38: 1477–1480, 1962.
2.
BertelliA., BonmassarE., GenoveseE., e TrabucchiE.Jr.: Sopravvivenza di omoinnesti cutanei in ratti trattati con il derivato acetilico dell'acido epsilon-amino-caproico.Atti Accad. Med. Lombarda, 18: 205–215, 1963.
3.
BertelliA., ProtoM., e RossanoM. A.: Azione inibente dell'acido epsilon-aminocaproico su fenomeni essudativi ed infiammatori.Atti Accad. Med. Lombarda, 17: 204–208, 1962.
4.
BonmassarE., PradaA., e RobottiC. A.: Il derivato acetilico dell'acido ∊-aminocaproico come favorente l'attecchimento e lo sviluppo del carcinoma di Ehrlich nel topo.Boll. Soc. It. Biol. Sper., 39: 1230–1232, 1963.
5.
CaglianiP., MarinoV., e SforzaM.: Somministrazione di inibitori della fibrinolisi e di antifibrinolisina e distribuzione ematogena delle metastasi del carcinosarcoma di Walker.Biol. Latina, 15: 171–175, 1962.
6.
ChrissanthouC., and AntopolW.: Effect of trypsin inhibitors on Shwartzman phenomenon.Proc. Soc. Exp. Biol. & Med., 108: 587–591, 1961.
7.
ClifftonE. E., AgostinoD., and MindeK.: The effect of hyperlipemia on pulmonary metastases of Walker 256 carcinosarcoma in the rat.Cancer Res., 21: 1062–1067, 1961.
8.
De NicolaP., SoardiF., und GibelliA.: Die antifibrinolytische Wirkung der ∊-Amino-capronsäure.Schweiz. Med. Wschr., 90: 1256–1257, 1960.
9.
DettoriA. G., e PonariO.: Attuali indirizzi di terapia negli stati iperfibrino-litici.Clin. Terap., 27: 97–114, 1963.
10.
FetterT. R., TocantinsL. M., CottoneR. N., BrosseauC., and BowmanW. D.: Effect of epsilon-aminocaproic acid on bleeding after prostatectomy.J. Urol., 85: 970–972, 1961.
11.
GilletteR. W., FindleyA., and ConwayH.: Effect of tumor homografts of treating hosts with antiproteolytic enzyme compounds.Proc. Soc. Exp. Biol. & Med., 112: 964–966, 1963.
12.
GrossiC. E., MoreroA. H., and RousselotL. M.: Studies on spontaneous fibrinolytic activity in patients with cirrhosis of the liver and its inhibition by epsilon-amino-caproic acid.Ann. Surg., 153: 383–393, 1961.
13.
ItogaG., and YogoT.: Inhibitory effect of epsilon-amino-caproic acid on the tuberculin reaction.Keio Med. J., 8: 299, 1959.
14.
LisnellA., and MellgrenJ.: Effect of heparin, protamine, dicoumarol, streptokinase and epsilon-amino-n-caproic acid on the growth of human cells in vitro. Acta Patol.Microbiol. Scandinav., 57: 145–153, 1963.
15.
Otto-ServaisM., et LecomteJ.: Inhibition par l'acide ∊-aminocaproïque des reactions anaphylactiques générales du lapin.C. R. Soc. Biol., 155: 2050–2052, 1961.
16.
RamosA. O., ChapmanL. F., CorradoA. P., FortesV. R., and FiorilloA. M.: Inhibition of the local Shwartzman phenomenon by the administration of epsilon-aminocaproic acid.Arch. Int. Pharm., 132: 270–273, 1961.
17.
VickJ. A., BlanchardR. J., and PerryJ. F.Jr.: Effect of epsilon amino caproic acid on pulmonary vascular changes produced by snake venom.Proc. Soc. Exp. Biol. Med., 113: 841–844, 1963.
