Abstract
Prostatic carcinoma causes early microemboli of tumour cells to the bone marrow, and frequent bone metastases. A myelogram was carried out in 30 subjects with established prostatic neoplasm, 6 of whom with radiologically evident bone metastases. Metastatic tumour cells were found in 2 cases only. In 16 cases the myelogram modification was unrelevant, in the remaining 12 cases some particular changes were demonstrated. These changes, although non-specific, seem to be the result of a conspicuous micro-embolism of tumour cells in the bone marrow; they consist in isolate or associate pictures of hyper-erythroblastosis, disproportionate to the degree of peripheral anemia, of plasmacell reaction, of reticular and lymphoidoreticular hyperplasia; the latter is related to particular changes of protein metabolism.
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