Abstract
In patients bearing disseminate metastases from breast cancer, treated by bilateral oophorectomy or hypophyseal radiosideration with Au198 or with Y90, the urinary elimination of 17-ketosteroids (60 cases), of corticosteroids (39 cases) and phenolsteroids (39 cases) has been studied.
The methods employed (Drekter's method for 17-ketosteroids, Heard, Sobel and Venning's method for corticosteroids, Jayle and Crepy's method for phenolsteroids) showed, in agreement with results by other investigators, the persistence of 17-ketosteroids and phenolsteroids elimination, even after interventions carried out for abolishing or eliminating the normal sources of production.
A comparison between elimination values for these two hormone groups and clinical response to endocrinosurgical treatment did not demonstrate a clear relationship between the residual production of such hormones and the subsequent evolution of the neoplastic process. However, in the patients treated with Au198, a better clinical result was found to be related to a more marked inhibition of the elimination values of urinary 17-ketosteroids.
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