Iperplasia Collaterale Nella Oncogenesi Sperimentale Del Ratto: 1. - Rilievi in corso di avitaminosi a combinata a depilazione

Abstract

Two lots, of 20 female rats each, were inoculated with 10 mg of 3,4-benzpyrene and submitted, one month later, to a Vitamin A-deficient diet. One of the lots was then subjected to periodic skin depilation in the site of tumour occurrence as well as in the contralateral side.

In the vitamin-deficient and depilated animals, a considerable hair reduction and hypoplasia was observed in the skin overlying the tumour, whereas such phenomenon appeared to be moderate in the animals only submitted to the Vitamin A-deficient diet. In all animals a hypoplasia of the sebaceous glands was observed, especially above the tumour. An epidermal hyperkeratosis was demonstrated in vitamin-deficient and depilated animals as well as in only vitamin-deficient ones, mainly at the tumour level.