The DNA modifications in medullary granuloblasts have been studied as « direct » effect as well as « indirect » or late effect of X-rays. For the purpose rabbits have been irradiated « in toto » after lead screening of two limbs. The modifications, consisting in a DNA increase, are cytologically expressed in the formation of giant cells, and have been obtained both as direct and indirect effect of X-rays.
These results, if considered as a biochemical and cytologic aspect of the carcinogenic action of radiation, constitute an experimental demonstration that this carcinogenic action must be looked upon also as an « indirect » or « late » effect.
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