The action of a new male hormone, the flusterone (9 α fluorine-11β hydroxi-17 methyltestosterone), has been studied on « in vitro » cultures of spontaneous mammary adenocarcinoma of the C3H mouse strain, and compared with that exerted by methyltestosterone and testosterone at the same concentrations. The three tested hormones showed a growth inhibiting action at the concentration of 100 γ/ml, slighter for methyltestosterone and testosterone and rather more marked for flusterone.
Get full access to this article
View all access options for this article.
References
1.
AstaldiG., MauriC., e AllegriA., Il Farmaco, 2, 532, 1947.
2.
Di MarcoA., e NeccoA., Tumori, 42, 519, 1956.
3.
HaamE., e CappelL., Am. J. Cancer, 39, 350, 1940.
4.
HestonW. E., DeringerM. K., Dunn T. B. e Levillain W. D., J. Nat. Cancer Inst., 10, 1139, 1950.
5.
LettréH., Cancer Research, 12, 857, 1952.
6.
MonesiV., Tumori, 42, 334, 1956.
7.
MühlbockO., Advances in Carcer Res., 4, 371, 1956.
8.
ParkerR. C., Methods of Tissue Culture, P. B. Hoeber Inc.New York, 1950.
9.
RingstedJ., Acta Path. et Micr. Scand., 40, 373, 1957.
10.
SirtoriC., La terapia medica dei tumori, Ed. CEA, Milano, 1953.