Abstract
Mitochondrial and microsomal fractions from normal and regenerating rat livers were isolated by differential centrifugation, Specific and aspecific antibodies were produced by intravenous injection of the above fractions into the rabbits ears.
The aspecific antibodies were adsorbed by a mixed suspension of rat kidney mitochondria and microsomes. The adsorbed antisera were tested with the normal and regenerating liver antigens in presence of a complete hemolytic system. It appeared that the complement was fixed either in presence of normal or regenerating liver antigens by the antibodies derived from both of them. Therefore it can be concluded that, in contrast with the hepatomas, the regenerating liver keeps its organ specificity, in spite of some of its biochemical features imitating the tumoral ones.
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