Testes of albino mice treated with 1–4 dimethansulfonoxybutane for different periods (15 and 30 days) and with different doses (25-50-100 γ) have been histologically studied. After 15 days treatment unsignificant lesions were observed independently of the employed dose, while after 30 days the seminiferous epithelium had disappeared and azoospermia with remarkable hyperplasia of the leydighian system were noticed. On the basis of the results obtained some considerations are exposed.
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