Abstract
A statistical study on tumour heredity has been carried out on 251 women (probands) bearing uterus carcinoma (185 cervical carcinomas and 66 corpus carcinomas) and on 251 healthy subjects (controls). 3575 relatives of the probands and 3578 of the controls were examined (parents, grandparents, uncles and aunts, collaterals, sons).
219 relatives of the probands (6,12 per cent) and 131 (3,66 per cent) of the controls were found to be or to have been affected by malignant tumours.
Among the female relatives of the probands the 2,49 per cent resulted to be affected by uterus carcinoma, among those of the controls only the 1,17 per cent.
As for tumour incidence, no significant differences have been observed between relatives of probands with cervical carcinoma and with uterus carcinoma. The neoplastic incidence in all sites was found to be moderately higher in relatives of probands bearing corpus carcinoma (6,57 per cent) than in those of probands bearing cervix carcinoma (5,94 per cent). Among the relatives of these two groups of probands (with cervix and uterus carcinomas) no remarkable differences weer observed as concerns tumour incidence.
A three-times higher neoplastic incidence of genital organs and prostata was observed among male relatives of the probands in comparison with male relatives of the controls.
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