Abstract
A lymphocytolytic hormone (ACTH) and a carcinogenic substance with general and protrected action (AAF) were administared to rats in order to induce hyperdysplastic-neoplastic processes in the lymphatic tissue. Microscopical examinations were performed (at different time intervals) on some organs (liver, spleen, thymus, testis, intestine, kidney, adrenals, lymph nodes) of the animals treated with the carcinogen alone as well as of those treated by the combined administration ACTH + AAF. High dosage (50 U.I. pro die for 10 days) of ACTH did not induce proliferative changes in the lymphatic tissue, except for a slight hyperplasia. True preneoplastic changes were obtained only in the liver of animals submitted to combined treatment.
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