Agar inserted into the subcutaneous tissue of rats gives rise to a granuloma with a peculiar structure. When methylcholanthrene is included in the agar the organization and the evolution of the granuloma are inhibited. Also when agar is inserted in the connective surrounding the Walker carcinoma or into the subcutaneous tissue of a tumour-bearing rat, quite an atypical granuloma is produced. It may be assumed that in such conditions the reaction properties of the connective tissue are modified.
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