The purpose of this article is to discuss the published evidence related to quality of life (QoL) and financial toxicity (FT) differences between female and male head and neck cancer patients treated with (chemo)radiotherapy. There is a need of promoting methods for assessing QoL difference between female and male patients in order to set up early rehabilitation, psychosocial care, and lifestyle interventions, as well as setting up specific interventions for minimizing financial stress.
BrayFFerlayJSoerjomataramI, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin2018; 68: 394-424.
2.
HashibeMBrennanPBenhamouS, et al. Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. J Natl Cancer Inst2007; 99: 777-89.
3.
MehannaHBeechTNicholsonT, et al. Prevalence of human papillomavirus in oropharyngeal and noropharyngeal head and neck cancer-systematic review and meta-analysis of trends by time and region. Head Neck2013; 35: 747-55.
4.
WindonMJD'SouzaGRettigEM, et al. Increasing prevalence of human papillomavirus-positive oropharyngeal cancers among older adults. Cancer2018; 124: 2993-2999.
5.
Oertelt-PrigioneSDe RooijBHMolsF, et al. Sex-differences in symptoms and functioning in >5000 cancer survivors: Results from the PROFILES registry. Eur J Cancer2021; 156: 24-34.
National Comprehensive Cancer Network (NCCN). Guidelines Head and Neck Cancers, Version 3.2021, April27, 2021, https://www.nccn.org (accessed 29 September 2021).
9.
BaudeletMVan den SteenLTomassenP, et al. Very late xerostomia, dysphagia, and neck fibrosis after head and neck radiotherapy. Head Neck2019; 41: 3594-3603.
10.
BenchetritLTorabiSJTateJP, et al. Gender disparities in head and neck cancer chemotherapy clinical trials participation and treatment. Oral Oncol2019; 94: 32-4.
11.
Abdel-RahmanO.Sex-based differences in outcome of patients with HPV-positive versus HPV-negative oropharyngeal carcinoma: a population-based study. Expert Rev Anticancer Ther2020; 20: 813-818
12.
MachielsJPRené LeemansCGolusinskiW, et al. Squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx: EHNS-ESMO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol2020; 31: 1462-1475.
13.
MartaGNSilvaVDe Andrade CarvalhoH, et al. Intensity-modulated radiation therapy for head and neck cancer: systematic review and meta-analysis. Radiother Oncol2014; 110: 9-15.
14.
PadillaGVFerrellBGrantMM, et al. Defining the content domain of quality of life for cancer patients with pain. Cancer Nurs1990; 13: 108-15.
15.
AaronsonNKAhmedzaiSBergmanB, et al. The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst1993; 85: 365-76.
16.
GrecoAOrlandiEMirabileA, et al. Italian version of the M.D. Anderson Symptom Inventory-Head and Neck Module: linguistic validation. Support Care Cancer2015; 23: 3465-3472.
17.
BjordalKDe GraeffAFayersPM, et al. A 12 country field study of the EORTC QLQ-C30 (version 3.0) and the head and neck cancer specific module (EORTC QLQ-H&N35) in head and neck patients. EORTC Quality of Life Group. Eur J Cancer2000; 36: 1796-807.
18.
ListMAD'AntonioLLCellaDF, et al. The performance status scale for head and neck cancer patients and the functional assessment of cancer therapy-head and neck scale. A study of utility and validity. Cancer1996; 77(11): 2294-301.
19.
ViganòADe FeliceFIacovelliNA.Anderson symptom inventory head neck (MDASI-HN) questionnaire: Italian language psychometric validation in head and neck cancer patients treated with radiotherapy ± systemic therapy - A study of the Italian Association of Radiotherapy and Clinical Oncology (AIRO). Oral Oncol2021; 115: 105189.
20.
SingerSAmdalCDHammerlidE, et al. EORTC Quality of Life and the EORTC Head and Neck Cancer Groups. International validation of the revised European Organisation for Research and Treatment of Cancer Head and Neck Cancer Module, the EORTC QLQ-HN43: Phase IV. Head Neck2019; 41: 1725-1737.
21.
SoWKChanRJChanDN, et al. Quality-of-life among head and neck cancer survivors at one year after treatment - a systematic review. Eur J Cancer2012; 48: 2391-408.
22.
PudD.Gender differences in predicting quality of life in cancer patients with pain. Eur J Oncol Nurs2011; 15: 486-91.
23.
HjermstadMJFayersPMBjordalK, et al. Health-related quality of life in the general Norwegian population assessed by the European Organization for Research and Treatment of Cancer Core Quality-of-Life Questionnaire: the QLQ=C30 (+ 3). J Clin Oncol1998; 16: 1188-1196.
24.
WaldmannASchubertDKatalinicA.Normative data of the EORTC QLQ-C30 for the German population: a population-based survey. PLoS One2013; 8: e74149.
25.
ArrarasJINolteSLieglG, et al. EORTC Quality of Life Group. General Spanish population normative data analysis for the EORTC QLQ-C30 by sex, age, and health condition. Health Qual Life Outcomes2021; 19: 208.
26.
HammerlidEBjordalKAhlner-ElmqvistM, et al. A prospective study of quality of life in head and neck cancer patients. Part I: at diagnosis. Laryngoscope2001; 111: 669-680.
27.
BjordalKAhlner-ElmqvistMHammerlidE, et al. A prospective study of quality of life in head and neck cancer patients. Part II: Longitudinal data. Laryngoscope2001; 111: 1440-52.
28.
PageYGuoPHanZ, et al. Quality of life differences in male and female patients with head and neck cancer. Int J Radiat Oncol Biol Phys2018; 102: E741.
SmithJCJohnsonJTCognettiDM, et al. Quality of life, functional outcome, and costs of early glottic cancer. Laryngoscope2003; 113: 68-76.
31.
ChanRJGordonLGTanCJ, et al. Relationships between financial toxicity and symptom burden in cancer survivors: a systematic review. J Pain Symptom Manage2019; 57: 646-660.e1.
32.
BaddourKKudrickLDNeopaneyA, et al. Potential impact of the COVID-19 pandemic on financial toxicity in cancer survivors. Head Neck2020; 42: 1332-1338.
33.
IsakssonJWilmsTLaurellG, et al. Meaning of work and the process of returning after head and neck cancer. Support Care Cancer2016; 24: 205-213.
34.
BeelerWHBellileELCasperKA, et al. Patient-reported financial toxicity and adverse medical consequences in head and neck cancer. Oral Oncol. 2020; 101: 104521.
35.
De SouzaJAKungSO'ConnorJ, et al. Determinants of patient-centered financial stress in patients with locally advanced head and neck cancer. J Oncol Pract, 2017; 13: e310-e318.
