Primary breast melanoma is a rare entity that on routine histology may be mistaken for triple-negative breast cancer. A high degree of clinical suspicion is necessary to make this diagnosis. This case report describes the presentation and treatment of primary breast melanoma.
KurulS., TasF., BuyukbabaniN., MudunA., BaykalC., CamlicaH.: Different manifestations of malignant melanoma in the breast: a report of 12 cases and a review of the literature.Jpn J Clin Oncol, 35: 202–206, 2005.
2.
StephensonS.E.Jr., ByrdB.J.Jr.: Malignant melanoma of the breast.Am J Surg, 97: 232–235, 1959.
3.
O'DonnellM.E., McCavertM., CarsonJ., MullanF.J., WhitesideM.W., GarstinW.I.: Non-epithelial malignancies and metastatic tumours of the breast.Ulster Med J, 78: 105–112, 2009.
4.
AlzaraaA., SharmaN.: Primary cutaneous melanoma of the breast: a case report.Cases J, 1: 212, 2008.
5.
LeeY.T., MortonD.L.: Primary melanoma of skin of the breast region.Ann Surg, 185: 17–22, 1977.
6.
BonoA., BaldiM., MaurichiA., TomatisS.: Distribution of melanoma on breast surface suggests its etiology.Int J Cancer, 105: 434, 2003.
7.
PapachristouD.N., KinneD.W., RosenP.P., AshikariR., FortnerJ.G.: Cutaneous melanoma of the breast.Surgery, 85: 322–328, 1979.
8.
HeatonK.M., SussmanJ.J., GershenwaldJ.E., LeeJ.E., ReintgenD.S., MansfieldP.F., RossM.I.: Surgical margins and prognostic factors in patients with thick (>4mm) primary melanoma.Ann Surg Oncol, 5: 322–328, 1998.
9.
MarkovicS.N., EricksonL.A., RaoR.D., WeenigR.H., PockajB.A., BardiaA., VachonC.M., SchildS.E., McWilliamsR.R., HandJ.L., LamanS.D., KottschadeL.A., MaplesW.J., PittelkowM.R., PulidoJ.S., CameronJ.D., CreaganE.T.: Malignant melanoma in the 21st century, part 2: staging, prognosis, and treatment.Mayo Clin Proc, 82: 490–513, 2007.
10.
KhanM.K., KhanN., AlmasanA., MacklisR.: Future of radiation therapy for malignant melanoma in an era of newer, more effective biological agents.Onco Targets Ther, 4: 137–148, 2011.
11.
BalloM.T., AngK.K.: Radiotherapy for cutaneous malignant melanoma: rationale and indications.Oncology, 18: 99–107, 2004.
VaughanA., DietzJ.R., MoleyJ.F., DebenedettiM.K., AftR.L., GillandersW.E., EberleinT.J., RitterJ., MargenthalerJ.A.: Metastatic disease to the breast: the Washington University experience.World J Surg Oncol, 5: 74, 2007.
14.
WilliamsS.A., EhlersR.A., HuntK.K., YiM., KuererH.M., SingletaryS.E., RossM.I., FeigB.W., SymmansW.F., Meric-BernstamF.: Metastases to the breast from nonbreast solid neoplasms: presentation and determinants of survival.Cancer, 110: 731–737, 2007.
15.
LoffeldA., MarsdenJ.R.: Management of melanoma metastasis to the breast: case series and review of the literature.Br J Dermatol, 152: 1206–1210, 2005.
16.
ToombsB., KalisherL.: Metastatic disease to the breast: clinical, pathologic, and radiographic features.Am J Roengenol, 129: 673–676, 1977.
17.
JanniW., RackB., SommerH., SchmidtM., StroblB., RjoskD., KlannerE., ThielekeW., GerberB., FrieseK., DimpflT.: Intramammary tumor location does not influence prognosis but influences the prevalence of axillary lymph-node metastases.J Cancer Clin Res Oncol, 129: 503–510, 2003.
18.
RavdelL., RobinsonW.A., LewisK., GonzalezR.: Metastatic melanoma in the breast: a report of 27 cases.J Surg Oncol, 94: 101–104, 2006.
RoyS., DhingraK., MandalS., KhuranaN.: Unusual presentation of metastatic amelanotic melanoma of unknown primary origin as a solitary breast lump.Melanoma Res, 18: 447–450, 2008.
21.
SheffieldM.V., YeeH., DorvaultC.C., WeilbaecherK.N., EltoumI.A., SiegalG.P., FisherD.E., ChiengD.C.: Comparison of five antibodies as markers in the diagnosis of melanoma in cytologic preparations.Am J Clin Pathol, 118: 930–936, 2002.
22.
de VriesT.J., SmeetsM., de GraafR., Hou-JensenK., BrockerE.B., RenardN., EggermontA.M., van MuijenG.N., RuiterD.J.: Expression of gp100, MART-1, tyrosinase and S100 in paraffin-embedded primary melanomas and locoregional, lymph node, and visceral metastases: implications for diagnosis and immunotherapy. A study conducted by the EORTC Melanoma Cooperative Group.J Pathol, 193: 13–20, 2001.
