Hypofractionation in Current Clinical Practice: A Flash Forward to the near Future of Radiation Oncology?

Atti XXI CONGRESSO NAZIONALE AIRO, Genova, 19–22 novembre 2011.

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Bentzen S.M. , Agrawal R.K. , Aird E.G. , Barrett J.M. , Barrett-Lee P.J. , Bliss J.M. , Brown J. , Dewar J.A. , Dobbs H.J. , Haviland J.S. , Hoskin P.J. , Hopwood P. , Lawton P.A. , Magee B.J. , Mills J. , Morgan D.A. , Owen J.R. , Simmons S. , Sumo G. , Sydenham M.A. , Venables K. , Yarnold J.R. : The UK Standardisation of Breast Radiotherapy (START) Trial A of radiotherapy hypofractionation for treatment of early breast cancer: A randomised trial. Lancet Oncol, 9: 331–341, 2008.

Bentzen S.M. , Agrawal R.K. , Aird E.G. , Barrett J.M. , Barrett-Lee P.J. , Bliss J.M. , Brown J. , Dewar J.A. , Dobbs H.J. , Haviland J.S. , Hoskin P.J. , Hopwood P. , Lawton P.A. , Magee B.J. , Mills J. , Morgan D.A. , Owen J.R. , Simmons S. , Sumo G. , Sydenham M.A. , Venables K. , Yarnold J.R. : The UK Standardisation of Breast Radiotherapy (START) Trial B of radiotherapy hypofractionation for treatment of early breast cancer: A randomised trial. Lancet, 371: 1098–1107, 2008.

Owen J.R. , Ashton A. , Bliss J.M. , Homewood J. , Harper C. , Hanson J. , Haviland J. , Bentzen S.M. , Yarnold J.R. : Effect of radiotherapy fraction size on tumour control in patients with early-stage breast cancer after local tumour excision: long-term results of a randomised trial. Lancet Oncol, 7: 467–471, 2006.

Whelan T.J. , Pignol J.P. , Levine M.N. , Julian J.A. , MacKenzie R. , Parpia S. , Shelley W. , Grimard L. , Bowen J. , Lukka H. , Perera F. , Fyles A. , Schneider K. , Gulavita S. , Freeman C. : Long-term results of hypofractionated radiation therapy for breast cancer. N Engl J Med, 362: 513–520, 2010.

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Brenner D.J. , Martinez A.A. , Edmundson G.K. , Mitchell C. , Thames H.D. , Armour E.P. : Direct evidence that prostate tumors show high sensitivity to fractionation (low alpha/beta ratio), similar to late-responding normal tissue. Int J Radiat Oncol Biol Phys, 52: 6–13, 2002.

Fowler J.F. , Ritter M.A. , Chappell R.J. , Brenner D.J. : What hypofractionated protocols should be tested for prostate cancer? Int J Radiat Oncol Biol Phys, 56: 1093–1104, 2003.

Brenner D.J. : Fractionation and late rectal toxicity. Int J Radiat Oncol Biol Phys, 60: 1013–1015, 2004.

Nahum A.E. , Movsas B. , Horwitz E.M. , Stobbe C.C. , Chapman J.D. : Incorporating clinical measurements of hypoxia into tumor local control modeling of prostate cancer: implications for the alpha/beta ratio. Int J Radiat Oncol Biol Phys, 57: 391–401, 2003.

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Kavanagh B.D. , Timmerman R.D. , Benedict S.H. , Wu Q. , Schefter T.E. , Stuhr K. , McCourt S. , Newman F. , Cardinale R.M. , Gaspar L.F. : How should we describe the radiobiologic effect of extracranial stereotactic radiosurgery: equivalent uniform dose or tumor control probability? Med Phys, 30: 321–324, 2003.

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Alongi F. , Di Muzio N. , Motta M. , Broggi S. , De Martin E. , Bolognesi A. , Cattaneo M. , Calandrino R. , Fazio F. : Adenoid cystic carcinoma of trachea treated with adjuvant hypofractionated tomotherapy. Case report and literature review. Tumori, 94: 121–125, 2008.

Kang J.K. , Cho C.K. , Choi C.W. , Yoo S. , Kim M.S. , Yang K. , Yoo H. , Kim J.H. , Seo Y.S. , Lee D.H. , Jo M. : Image-guided stereotactic body radiation therapy for localized prostate cancer. Tumori, 97: 43–48, 2011.

Shin Y.J. , Kim M.S. , Yoo S.Y. , Cho C.K. , Seo Y.S. , Kang J.K. , Park S.C. , Han C.J. , Kim S.B. , Lee B.H. , Lees D.H. : Pilot study of stereotactic body radiotherapy for huge hepatocellular carcinoma unsuitable for other therapies. Tumori, 96: 65–70, 2010.

Maranzano E. , Anselmo P. , Casale M. , Trippa F. , Carletti S. , Principi M. , Loreti F. , Italiani M. , Caserta C. , Giorgi C. : Treatment of recurrent glioblastoma with stereotactic radiotherapy: long-term results of a mono-institutional trial. Tumori, 97: 56–61, 2011.