The female genital tract is an infrequent site of metastasis, in particular from extragenital primary tumors such as non-small cell lung cancer. Ovarian metastases have been described as disseminations of lung adenocarcinoma; rare cases of secondary localizations in adnexa, cervix and vagina were also observed in the literature, but none of these had endometrial involvement. We report the first case, to our knowledge, of non-small cell lung cancer with metastatic spread to the endometrium.
IrvingJ.A., YoungR.H.: Lung carcinoma metastatic to the ovary. A clinicopathologic study of 32 cases emphasizing their morphologic spectrum and problems in differential diagnosis.Am J Surg Pathol, 29: 997–1006, 2005.
2.
CastadotP., MagnéN., BerghmansT., DrowartA., BaeyensL., SmetsD., Van HoutteP.: Métastase ovarienne et adenocarcinoma pulmonaire: observation d'un case clinique.Cancer/Radiothérapie, 9: 183–186, 2005.
3.
ChenM.Y., JungS.M., NgK.K., ChangT.C.: Pulmonary papillary serous adenocarcinoma with intraperitoneal and ovarian tumors: identification of primary site. A case report.Int J Gynecol Cancer, 16(Suppl 1): 231–235, 2006.
JahnkeA., DomkeR., MakovitzkyJ., NizzeH., BrieseW.: Vaginal metastasis of lung cancer: a case report.Anticancer Res, 25: 1645–1648, 2005.
6.
PeedellC., DykesR.: An unusual case of non-small cell lung cancer presenting with renal angle pain and hematuria.J Thorac Oncol, 2: 671–672, 2007.
7.
KaiK., TakaiN., NasuK., KiraN., IshiiT., KashimaK., NaraharaH.: Metastatic uterine cervical cancer originating in the lung: a case report.Gynecol Obstet Invest, 68: 269–271, 2009.
8.
ChargariC., VedrineL.: Métastase uterine d'un cancer pulmonaire à petites cellules.Rev Med Interne, 29: 591–592, 2008.
9.
JordanC.D., AndrewsS.J., MemoliV.A.: Well-differentiated pulmonary neuroendocrine carcinoma metastatic to the endometrium: a case report.Mod Pathol, 9: 1066–1070, 1996.
10.
TravisW.D., BrambillaE., Müller-HermelinkH.K., HarrisC.C. (Eds): World Health Organization Classification of Tumours.Pathology and genetics of tumours of the lung, pleura, thymus and heart, pp 35–44, IARC Press, Lyon, 2004.
11.
ChuP., WuE., WeissL.M.: Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasms: a survey of 435 cases.Mod Pathol, 13: 962–972, 2000.
12.
KaufmannO., KötherS., DietelM.: Use of antibodies against estrogen and progesterone receptors to identify metastatic breast and ovarian carcinomas by conventional immunohistochemical and tyramide signal amplification methods.Mod Pathol, 11: 357–363, 1998.
