Drug-induced acute thrombocytopenia is an extremely rare side effect that may occur immediately after oxaliplatin infusion. This potentially fatal reaction is immune mediated and can be anticipated by mild hemorrhagic signs during previous administrations. This is the first report of acute thrombocytopenia occurring during adjuvant treatment of colorectal cancer with oxaliplatin. Clinicians should be aware of this adverse event in order to prevent possible serious consequences and stop further oxaliplatin administration.
MaloiselF., KurtzJ.E., AndresE., GorodetskyC., DufourP., OberlingF.: Platin salts-induced hemolytic anemia: cisplatin- and the first case of carboplatin-induced hemoly-sis. Anticancer Drugs, 6: 324–326, 1995.
2.
ChenV.M., ThriftK.M., Morel-KoppM.C., JacksonD., WardC.M., FlowerR.L.: An immediate hemolytic reaction induced by repeated administration of oxaliplatin. Transfusion, 44: 838–843, 2004.
3.
CoboF., De CelisG., PereiraA., LatorreX., PujadasJ., AlbiolS.: Oxaliplatin-induced immune hemolytic anemia: a case report and a review of the literature. Anticancer Drugs, 18: 973–976, 2007.
4.
GarufiC., VaglioS., BrienzaS., ContiL., D'AttinoR.M., GirelliG., TerzoliE.: Immunohemolytic anemia following oxaliplatin administration. Ann Oncol, 11: 497, 2000.
HofheinzR.D., NguyenX.D., BuchheidtD., KerowganM., HehlmannR., HochhausA.: Two potential mechanisms of oxaliplatin-induced haemolytic anaemia in a single patient. Cancer Chemother Pharmacol, 53: 276–277, 2004.
SørbyeH., BruserudY., DahlO.: Oxaliplatin-induced haematological emergency with an immediate severe thrombocytopenia and haemolysis. Acta Oncol, 40: 882–883, 2001.
9.
DoldF.G., MitchellE.P.: Sudden-onset thrombocytopenia with oxaliplatin. Ann Intern Med, 139: 156–157, 2003.
CurtisB.R., KaliszewskiJ., MarquesM.B., SaifM.W., NabelleL., BlankJ., McFarlandJ.G., AsterR.H.: Immune-mediated thrombocytopenia resulting from sensitivity to oxaliplatin. Am J Hematol, 81: 193–198, 2006.
13.
DahabrehI., TsoutsosG., TseligasD., JaninisD.: Hemolytic uremic syndrome following the infusion of oxaliplatin: case report. BMC Clin Pharmacol, 6: 5, 2006.
