Primary pancreatic lymphoma is non-Hodgkin lymphoma primarily involving the pancreas, which is rare in pancreatic diseases. The aim of this work is to summarize the diagnostic and therapeutic experience of primary pancreatic lymphoma.
Methods
We retrospectively reviewed the clinical data of 7 cases of primary pancreatic lymphoma admitted to Huashan Hospital in the past 3 years. Available English literature was also reviewed using the following terms: primary pancreatic lymphoma and pancreatic lymphoma.
Results
The literature review identified 157 additional cases, and a total of 164 cases had been analyzed. In this series, only 30% had a successful non-operative diagnosis. The curative rate of the surgery-adjuvant chemotherapy group was higher than that of the chemotherapy alone group.
Conclusions
Obtaining specimens through surgery is an effective diagnostic tool. Surgical resection in combination with postoperative chemotherapy plays a therapeutic role.
RosenbergS.A., DiamondH.D., JaslowitzB., CraverL.F.: Lymphosarcoma: a review of 1269 cases. Medicine, 40: 31–84, 1961.
2.
SalvatoreJ.R., CooperB., ShahI., KummetT.: Primary pancreatic lymphoma: a case report, literature review, and proposal for nomenclature. Med Oncol, 17: 237–247, 2000.
3.
ZuccaE., RoggeroE., BertoniF., CavalliF.: Primary extranodal non-Hodgkin's lymphomas. Part 1: Gastrointestinal, cutaneous and genitourinary lymphomas. Ann Oncol, 8: 727–737, 1997.
4.
BehrnsK.E., SarrM.G., StricklerJ.G.: Pancreatic lymphoma: is it a surgical disease?Pancreas, 9: 662–667, 1994.
5.
RosenbergS.A.: Validity of the Ann Arbor staging classification for the non-Hodgkin's lymphomas. Cancer Treat Rep, 61: 1023–1027, 1977.
6.
ArcariA., AnselmiE., BernuzziP., BertèR., LazzaroA., MoroniC.F., TrabacchiE., VallisaD., VercelliA., CavannaL.: Primary pancreatic lymphoma. A report of five cases. Haematologica, 90: ECR09, 2005.
NishimuraR., TakakuwaT., HoshidaY., TsujimotoM., AozasaK.: Primary pancreatic lymphoma: clinicopathological analysis of 19 cases from Japan and review of the literature. Oncology, 60: 322–329, 2001.
11.
BernardeauM., AurouxJ., CavicchiM., HaiounC., TsakirisL., DelchierJ.C.: Secondary pancreatic involvement by diffuse large B-cell lymphoma presenting as acute pancreatitis: treatment and outcome. Pancreatology, 2: 427–430, 2002.
12.
EisenhuberE., SchoeflR., WiesbauerP., BankierA.A.: Primary pancreatic lymphoma presenting as acute pancreatitis in a child. Med Pediatr Oncol, 37: 53–54, 2001.
13.
TurkishA., LevyJ., KatoM., GranowetterL., Ruzal-ShapiroC., BerdonW., SusmanJ., LefkowitchJ.: Pancreatitis and probable paraneoplastic cholestasis as presenting manifestations of pancreatic lymphoma in a child. J Pediatr Gastroenterol Nutr, 39: 552–556, 2004.
SavopoulosC.G., TsesmeliN.E., KaiafaG.D., ZantidisA.T., BobosM.T., HatzitoliosA.I., PapavramidisS.T., KostopoulosI.S.: Primary pancreatic anaplastic large cell lymphoma, ALK negative: a case report. World J Gastroenterol, 11: 6221–6224, 2005.
21.
OzgürogluM., TurnaH., DemirG., DöventasA., DemirelliF., MandelN.M., BüyükünalE., SerdengeçtiS., BerkardaB.: Usefulness of the epithelial tumor marker CA-125 in non-Hodgkin's lymphoma. Am J Clin Oncol, 22: 615–618, 1999.
22.
MatsubayashiH., TakagakiS., OtsuboT., IiriT., KobayashiY., YokotaT., ShichijoK., IwafuchiM., KijimaH.: Pancreatic T-cell lymphoma with high level of soluble interleukin-2 receptor. J Gastroenterol, 37: 863–867, 2002.
23.
HartM.J., WhiteT.T., BrownP.C., FreenyP.C.: Potentially curable masses in the pancreas. Am J Surg, 154: 134–136, 1987.
24.
KoniarisL.G., LillemoeK.D., YeoC.J., AbramsR.A., ColemannJ., NakeebA., PittH., CameronJ.L.: Is there a role for surgical resection in the treatment of early stage pancreatic lymphoma?J Am Coll Surg, 190: 319–330, 2000.
25.
ShaharK.H., CarpenterL.S., JorgensenJ., TruongL., BakerK., TehB.S.: Role of radiation therapy in a patient with primary pancreatic lymphoma. Clin Lymphoma Myeloma, 6: 143–145, 2005.
26.
BasuA., PatilN., MohindraP., ZadeB., GujralS., MuckadenM.A., LaskarS.: Isolated non-Hodgkin's lymphoma of the pancreas: case report and review of literature. J Cancer Res Ther, 3: 236–239, 2007.
