This report describes a case of prostate adenocarcinoma presenting with supraclavicular adenopathy and deep venous thrombosis in the ipsilateral arm. Biopsy revealed the enlarged node to be an undifferentiated adenocarcinoma of unknown origin, while CT scan evidenced widespread adenopathies. Because of the increase in serum PSA, the immunohistochemical staining of the biopsy specimen was reviewed and strong positivity for PSA suggested a prostatic origin. We emphasize the importance of PSA immunohistochemistry and serum PSA level monitoring in men presenting with carcinoma of undetermined origin and generalized lymphadenopathies.
JemalA., MurrayT., WardE., SamuelsA., TiwaniR.C., GhafoorA., FeuerE.J., ThunM.J.: Cancer statistics 2005. CA Cancer J Clin2005, 55: 10–30. Erratum in CA Cancer J Clin, 55: 259, 2005.
2.
ChitaleS.V., HarryL., GachesC.G., BallR.Y.: Presentation of prostatic adenocarcinoma with cervical lymphadenopathy: two case reports and review of the literature. Otolaryngol Head Neck Surg, 125: 431–432, 2001.
3.
ChoK.R., EpsteinJ.L.: Metastatic prostatic carcinoma to supradiaphragmatic lymph nodes. A clinicophatologic and immunohistochemical study. Am J Surg Pathol, 11: 457–463, 1987.
4.
JonesH., AnthonyP.P.: Metastatic prostatic carcinoma presenting as left-sided cervical lymphadenopathy. A series of 11 cases. Histopathology, 21: 149–154, 1992.
5.
HeresiG.A., WangJ., TaichmanR., ChirinosJ.A., RegaladoJ.J., LichtsteinD.M., RosenblattJ.D.: Expression of the chemokine receptor CCR7 in prostate cancer presenting with generalized lymphadenopathy: report of a case, review of the literature, and analysis of chemokine receptor expression. Urol Oncol, 23: 261–267, 2005.
6.
BiyaniC.S., BasuS., BottomleyD.M., ShahT.K.: Prostatic adenocarcinoma masquerading as lymphoma and presentation with axillary-subclavian vein thrombosis. Urol Oncol, 21: 3–6, 2003.
7.
SteinB.S., SheaF.J.: Metastatic carcinoma of the prostate presenting radiographically as lymphoma. J Urol, 130: 362–364, 1983.
8.
FuruyaY., AkakuraK., AkimotoS., ItoH.: Prognosis of patients with prostate carcinoma presenting as nonregional lymph node metastases. Urol Int, 61: 17–21, 1998.
