The presence of an adrenal gland nodule may be an early or late sign of metastatic spread from colorectal cancer. It usually appears when the internal malignancy is widely disseminated and has been previously diagnosed. Adrenal insufficiency can be compatible with bilateral and diffuse involvement of this uncommon site of disease. Although a surgical approach can be proposed in some circumstances, chemotherapy is usually the only therapeutic option. We present 2 cases that document examples of both events, so as to illustrate the most relevant aspects of this condition.
CedermarkB.J.BlumensonL.E.PickrenJ.W.HolyokeD.E.EliasE.G.: The significance of metastases to the adrenal glands in adenocarcinoma of the colon and rectum.Surg Gynecol Obstet, 144: 537–546, 1977.
4.
HenifordB.T.ArcaM.J.WalshR.M.GillI.S.: Laparoscopic adrenalectomy for cancer.Semin Surg Oncol, 16: 293–306, 1999.
5.
OmoiguiN.A.CaveW.T.Jr.ChangA.Y.: Adrenal insufficiency. A rare initial sign of metastatic colon carcinoma.J Clin Gastroenterol, 9: 470–474, 1987.
6.
CrisciA.CarteiG.De AntoniP.GiannariniG.MoroU.SelliC.: Surgical management of isolated bilateral adrenal metastases from colon carcinoma causing adrenal insufficiency.Urol Int, 67: 113–116, 2001.
