According to various authors the incidence of multiple primary tumors in the aerodigestive tract can be considered high. However, most of these tumors are metachronous and of the same histological type. The occurrence of a small cell lung carcinoma synchronous with a squamous cell vocal cord carcinoma is a very rare phenomenon. In this report we present the second case in the English literature.
GluckmanJ.L., CrissmanJ.D.: Survival rates in 548 patients with multiple neoplasms of the upper aerodigestive tract.Laryngoscope, 93: 71–74, 1983.
2.
StrigenzM.A., ToohillR.J., GrossmanT.W.: Association of laryngeal and pulmonary malignancies: a continuing challenge.Ann Otol Rhinol Laryngol, 96: 621–624, 1987.
3.
PanosettiE., LuboinskiB., MamelleG., RichardJ.M.: Multiple synchronous and metachronous cancers of the upper aerodigestive tract: a nine-year study.Laryngoscope, 99: 1267–1273, 1989.
4.
CooperJ.S., PajakT.F., RubinP., TupchongL., BradyL.W., LeibelS.A., LaramoreG.E., MarcialV.A., DavisL.W., CoxJ.D.: Second malignancies in patients who have head and neck cancer: incidence, effect on survival and implications based on the RTOG experience.Int J Rad Oncol Biol Phys, 17: 449–456, 1989.
5.
SchwartzL.H., OzsahinM., ZhangG.N., TouboulE., De VataireF., AndolencoP., Lacau-Saint-GuilyJ., LaugierA., SchliengerM.: Synchronous and metachronous head and neck carcinomas.Cancer, 74: 1933–1938, 1994.
DeviriE., BartalA., GoldsherM., EliacharI., SteinitzR., RobinsonE.: Occurrence of additional primary neoplasms in patients with laryngeal carcinoma in Israel (1960-1976).Ann Otol Rhinol Laryngol, 91: 261–265, 1982.
8.
HeeringaA., De VriesN., SnowG.B., StamJ.: Laryngeal cancer and lung cancer in the same patient: a retrospective study.Eur J Surg Oncol, 14: 209–211, 1988.
9.
BillrothT.Die algemeine Chirurgische Pathologie und Therapie in 51 Vorlesungen. In: Handbuch für Studierende und Aerzte, ReimerG. (Ed), 908, G Reimer, Berlin, 1889.
10.
LundgrenJ., OlofssonJ.: Multiple primary malignancies in patients treated for laryngeal carcinoma.J Otolaryngol, 15: 145–150, 1986.
11.
LicciardelloJ., SpitzM.R., HongW.K.: Multiple primary cancer in patients with cancer of the head and neck: second cancer of the head and neck, esophagus and lung.Int J Radiat Oncol Biol Phys, 17: 467–476, 1989.
12.
HordijkG.J., BrugginkT., RavaszL.A.: Panendoscopy: a valuable procedure?Otolaryngol Head Neck Surg, 101: 426–428, 1989.
13.
RobertsT.J., EpsteinB., LeeD.J.: Second neoplasms in patients with carcinomas of the vocal cord: incidence and implications for survival.Int J Radiat Oncol Biol Phys, 21: 583–589, 1991.
14.
LyonsM.F., RedmondJ., CovelliH.: Multiple primary neoplasia of the head and neck and lung.Cancer, 57: 2193–2197, 1986.
15.
WillettG.D., SchumannG.B., GenackL.: Primary cytodiagnosis of small-cell cancer and squamous-cell carcinoma of the respiratory tract.Acta Cytologica, 28: 610–613, 1984.
