Phase II Single-Agent Studies in Elderly Cancer Patients

Begg C.B. , Carbone P.P. : Clinical trials and drug toxicity in the elderly: the experience of the Eastern Cooperative Oncology Group. Cancer, 52: 1986–1992, 1983.

Begg C.B. , Elson P.J. , Carbone P.P. : A study of excess hematologic toxicity in elderly patients treated on cancer chemotherapy protocols. In: Yancik R , Yates JW (eds), Cancer in the elderly: approaches to early detection and treatment. Springer-Verlag, Berlin, 149–163, 1989.

Monfardini S. , Sorio R. , Hoctin Boes G. : Entry and evaluation of elderly patients in European Organization for Research and Treatment of Cancer (EORTC) New-Drug Development studies. Cancer, 76: 333–338, 1995.

Giovanazzi-Bannon S. , Rademaker A. , Lai G. : Treatment tolerance of elderly cancer patients entered onto phase II clinical trials: an Illinois Cancer Center study. J Clin Oncol, 12: 2447–2452, 1994.

Tirelli U. , Monfardini S. : Treatment of elderly patients with antineoplastic chemotherapy. J Clin Oncol, 13: 1282–1283, 1995.

Hutchins L.F. , Unger J.M. , Crowley J.J. : Underrepresentation of patients 65 years of age or older in cancer-treatment trials. N Eng J Med, 341: 2061–2067, 1999.

Monfardini S. , Sorio R. , Kaye S. : Should elderly cancer patients be entered in dose-escalation studies? Ann Oncol, 5: 964–966, 1994.

Vogel C. , O'Rourke M. , Winer E. : Vinorelbine as first-line chemotherapy for advanced breast cancer in women 60 years of age or older. Ann Oncol, 10: 397–402, 1999.

Buonadonna A. , Crivellari D. , Frustaci P. : Vinorelbine (VRL) as palliatiove treatment in elderly patients (pts) with metastatic breast cancer: final results. Proc ICACT, 103: 161, 1998.

Rossi A. , Gridelli C. , Manzione L. : Single agent vinorelbine in elderly patients with advanced breast cancer: a multicenter phase II study. Proc ASCO, 20: 1993, 2001.

Hainsworth J.D. , Burris H.A. , Yardley D.A. : Weekly docetaxel in the treatment of elderly patients with advanced breast cancer: a Minnie Pearl Cancer Reserach Network phase II trial. J Clin Oncol, 19: 3500–3505, 2001.

Carney D.N. , Grogan L. , Smit E.F. : Single-agent oral etoposide for elderly small cell lung cancer patients. Semin Oncol, 17: 49–53, 1990.

The Elderly Lung Cancer Vinorelbine Italian Study Group: Effects of vinorelbine on quality of life and survival of elderly patients with advanced non-small-cell lung cancer. J Natl Cancer Inst, 91: 66–72, 1999.

Altavilla G. , Adamo V. , Buemi B. : Gemcitabine as single agent in the tretment of elderly patients with advanced non small cell lung cancer. Anticancer Res, 20: 3675–3678, 2000.