AgelakiS., KouroussisC., MavroudisD., KalbasisK., SouglakosJ., ReppaD., MixakiI., GeorgouliasV.: A phase I study of docetaxel (D) and oxaliplatin (L-OHP) as front-line treatment in metastatic breast cancer (MBC) and non-small cell lung cancer (NSCLC).Proc. Am. Soc. Clin. Oncol.,19: 114a, 2000 (abstr. 443).
2.
BaselgaJ., PfisterD., CooperM.R., CohenR., BurtnessB., BosM., D'AndreaG., SeidmanA., NortonL., GunnettK., FalceyJ., AndersonV., WaksalH., MendelsohnJ.: Phase I studies of anti-epidermal growth factor receptor chimeric antibody C225 alone and in combination with cisplatin.J. Clin. Oncol., 18: 904–914, 2000.
3.
BedikianA.Y., LeghaS.S., EtonO., BuzaidA.C., PapadopoulosN., PlagerC., McIntyreS., VialletJ.: Phase II trial of escalated dose of tirapazamine combined with cisplatin in advanced malignant melanoma.Anticancer Drugs, 10: 735–739, 1999.
4.
BonomiP., KimK., FaircloughD., CellaD., KuglerJ., RowinskyE., JiroutekM., JohnsonD.: Comparison of survival and quality of life in advanced non-small-cell lung cancer patients treated with two dose levels of paclitaxel combined with cisplatin versus etoposide with cisplatin: results of an Eastern Cooperative Oncology Group trial.J. Clin. Oncol.,18: 623–631, 2000.
5.
CiardielloF., CaputoR., BiancoR., DamianoV., PomaticoG., De PlacidoS., BiancoA.R., TortoraG.: Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor.Clin. Cancer Res., 6: 2053–2063, 2000.
6.
ClarkeS., BoyerM., MilwardM., FindlayM., AcklandS., ChildsA., BrewS., WalcherY., WattD., CampbellL.: Multi-targeted antifolate MTA (LY231514): an active agent in advanced non-small cell lung cancer (NSCLC).Proc. Am. Soc. Clin. Oncol.,17: 466a, 1998 (abstr. 1793).
7.
CobleighM.A., VogelC.L., TripathyD., RobertN.J., SchollS., FehrenbacherL., WolterJ.M., PatonV., ShakS., LiebermanG., SlamonD.J.: Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease.J. Clin. Oncol., 17: 2639–2648, 1999.
8.
CorneliaP., FrasciG., PanzaN., ManzioneL., LorussoV., Di RienzoG., CioffiR., De CataldisG., MaiorinoL., BilanciaD., NicolellaG., NataleM., CarpagnanoF., PacilioC., De LenaM., BiancoA., CorneliaG.: Cisplatin, gemcitabine and vinorelbine combination therapy in advanced non-small cell lung cancer: a phase II randomized study of the Southern Italy Cooperative Oncology Group.J. Clin. Ocnol., 17: 1526–1534, 1999.
9.
CoussensL., Yang-FengT.L., LiaoY.C., ChenE., GrayA., McGrathJ., SeeburgP.H., LibermannT.A., SchlessingerJ., FranckeU.: Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene.Science, 230: 1123–1139, 1985.
10.
CrinòL., MosconiA.M., ScagliottiG., SelvaggiG., NovelloS., RinaldiM., Della GiuliaM., GridelliC., RossiA., CalandriC., De MarinisF., NosedaM., TonatoM.: Gemcitabine as second-line treatment for advanced non-small cell lung cancer. A phase II trial.J. Clin. Oncol., 17: 2081–2085, 1999.
11.
CrossM., DexterT.M.: Growth factors in the development, trasformation and tumorigenesis.Cell, 64: 271–280, 1991.
12.
CullenM.H., BillinghamL.J., WoodroffeC.M., ChetiyawardanaA.D., GowerN.H., JoshiR., FerryD.R., RuddR.M., SpiroS.G., CookJ.E., TraskC., BessellE., ConnollyC.K., TobiasJ., SouhamiR.L.: Mitomycin, ifosfamide, and cisplatin in unresectable non-small cell lung cancer: effects on survival and quality of life.J. Clin. Oncol., 17: 3188–3194, 1999.
13.
De CremouxH., BekraddaM., MonnetI., SoulièP., SaltielS., MissetJ.L., FandiA., BensmaineM.A., CvitkovicE.: Preliminary report on oxaliplatin (L-OHP/navelbine (NVB) phase I/II multicentric trial in patients (pts) with advanced non-small celli lung cancer (NSCLC): an active combination.Proc. Am. Soc. Clin. Oncol.,17: 481a, 1998 (abstr. 1852).
14.
DeVoreR.F., FehrenbacherL., HerbstR.S., LangerC.J., KellyK., GaudreaultJ., HolmgrenE., NovotnyW.F., KabbinavarF.: A randomized phase II trial comparing rhumab VEGF (recombinant humanized monoclonal antibody to vascular endothelial cell growth factor) plus carboplatin/paclitaxel (CP) to CP alone in patients with stage IIIB/IV NSCLC.Proc. Am. Soc. Clin. Oncol.,19: 485a, 2000 (abstr. 1896).
15.
FavarettoA., PaccagnellaA., OnigaF., TumoloS., BarbieriF., CeresoliG., GulisanoM., SchiavonS.: Paclitaxel and carboplatin with gemcitabine (PCG): a phase I-II trial in non-small cell lung cancer (NSCLC).Proc. Am. Soc. Clin. Oncol.,19: 512a, 2000 (abstr. 2003).
16.
FerryD., HammondL., RansonM., KrisM., MillerV., MurrayP., TulloA., FeyereislovaA., AverbuchS., RowinskyE.: Intermittent oral ZD1839 (Iressa), a novel epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), shows evidence of good tolerability and activity: final results from a phase I study.Proc. Am. Soc. Clin. Oncol.,19: 3a, 2000 (abstr. 5E).
17.
FontaniniG., BoldriniL., ChineS., PisaturoF., BasoloF., CalcinaiA., LucchiM., MussiA., AngelettiC.A., BevilacquaG.: Expression of vascular endothelial growth factor mRNA in non-small-cell lung carcinomas.Br. J. Cancer, 79: 363–369, 1999.
18.
FossellaF., DeVoreR., KerrR., CrawfordJ., NataleR., DunphyF., KalmanL., GandaraD., GamzaF., HammershaimbL., KimY., CristW.: Phase III trial of docetaxel 100 mg/m2 or 75 mg/m2 vs vinorelbine/ifosfamide for non-small cell lung cancer previously treated with platinum-based chemotherapy (PBC).Proc. Am. Soc. Clin. Oncol.,18: 460a, 1999 (abstr. 1776).
19.
FrasciG., PanzaN., CorneliaP., NicolellaG.P., NataleM., PacilioC., GravinaA., CaputiV., BottiG., CorneliaG.: Cisplatin, gemcitabine and vinorelbine in locally advanced or metastatic non-small cell lung cancer. A phase I study.Ann. Oncol., 8: 1045–1048, 1997.
20.
GattoC., RieppiM., BorsottiP., InnocentiS., CerutiR., DrudisT., ScanzianiE., CasazzaA.M., TarabolettiG., GiavazziR.: BAY 12-9566, a novel inhibitor of matrix metallo-proteinases with antiangiogenic activity.Clin. Cancer Res., 5: 3603–3607, 1999.
21.
GiacconeG., SmitE.F., van MeerbeeckJ.P., SplinterT., GoldingR.P., PinedoH.M., LaanD., van TinterenH., PostmusP.E.: A phase I-II study of gemcitabine and paclitaxel in advanced non-small cell lung cancer patients.Ann. Oncol., 11: 109–112, 2000.
22.
Gonzalez BaronM., GarciaM.J., ChaconJ.I., OrdonezA., MadronalC., MuriasA., CruzM.A., CastroJ., FeliuJ., ColmenarejoA., AguiaJ.: A phase II of gemcitabine, cisplatin, and vinorelbine in patients with advanced non-small cell lung cancer.Proc. Am. Soc. Clin. Oncol.,17: 469a, 1998 (abstr. 1802).
23.
GrauC., OvergaardJ.: Effect of cancer chemotherapy on the hypoxic fraction of a solid tumor measured using a local tumor control assay.Radiother. Oncol., 13: 301–309, 1988.
24.
GridelliC., FrontiniL., PerroneF., GalloC., GulisanoM., CigolariS., CastiglioneF., RobbiatiS.F., GaspariniG., IannielloG.P., FarrisA., LocatelliM.C., FellettiR., PiazzaE.: Gemcitabine plus vinorelbine in advanced non-small cell lung cancer: a phase II study of three different doses.Br. J. Cancer, 83: 707–714, 2000.
25.
ISTAT, Cause di morte, 1994.Roma, 1997.
26.
JarvisW.D., GrantS.: Protein kinase C targeting in antineoplastic treatment strategies.Invest. New Drugs, 17: 227–240, 1999.
27.
KarpD., SilbermanS., CsudaeR., WirthF., GaynesL., PosnerM., BubleyG., KoonH., BergmanM., HuangM., SchnipperL.E.: Phase I dose escalation study of epidermal growth factor recptor (EGFR) tyrosine kinase (TK) inhibitor CP-358.774 in patients with advanced solid tumors.Proc. Am. Soc. Clin. Oncol.,18: 388a, 1999 (abstr. 1499).
28.
KellyK., CrowleyJ., BunnP., LivingstonR.B., GandaraD.R.: Southwest Oncology Group: a randomized phase III trial of paclitaxel plus carboplatin (PC) versus vinorelbine plus cispaltin (VC) in untreated advanced non-small cell lung cancer (NSCLC): a Southwest Oncology Group Trial.Proc. Am. Soc. Clin. Oncol.,18: 461a, 1999 (abstr. 1777).
29.
KellyK., PrindivilleS., BunnP.A.Jr.: A phase I trial of paclitaxel (P), carboplatin (C), and gemcitabine (G) in advanced non-small cell lung cancer: A University of Colorado Cancer Centre study.Proc. Am. Soc. Clin. Oncol.,17: 490a, 1998 (abstr. 1885).
30.
LevinM., NovetskyA.: A phase II study of docetaxel, vinorelbine G-CSF chemotherapy in patients with unresectable or metastatic non-small cell cancer of the lung.Proc. Am. Soc. Clin. Oncol.,18: 514a, 1999 (abstr. 1982).
31.
LorussoV., CarpagnanoF., FrasciG., PanzaN., Di RienzoG., CisterninoM.L., NapoliG., OrlandoS., CinieriS., BrunettiC., PalazzoS., De LenaM.: Phase I/II study of gemcitabine plus vinorelbine as first-line chemotherapy of non-small cell lung cancer.J. Clin. Oncol., 18: 405–411, 2000.
32.
MattsonK., PawelJ.V., ManegoldC., PostmusP., ClarkeS.: MTA (Multitargeted Antifolate, LY231514) in NSCLC patients who failed previous platinum or non-platinum chemotherapy: a phase II trial.Proc. Am. Soc. Clin. Oncol.,18: 1892 (abstr.), 1999.
33.
MillerV.A., KrugL.M., NgK.K., PizzoB., PerezW., HeelanR.T., KrisM.G.: Phase II trial of docetaxel and vinorelbine in patients with advanced non-small-cell lung cancer.J. Clin. Oncol., 18: 1346–1350, 2000.
34.
MonnetI., BrienzaS., HugretF., VoisinS., GastiaburuJ., SaltielJ.C., SoulieP., ArmandJ.P., CvitkovicE., de CremouxH.: Phase II study of oxaliplatin in poor-prognosis non-small cell lung cancer (NSCLC).ATTIT. Association pour le Traitement des Tumeurs Intra Thoraciques. Eur. J. Cancer, 34: 1124–1127, 1998.
Non-small Cell Lung Cancer Collaborative Group:Chemotherapy in non-small cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomized clinical trials: Non-small Cell Lung Cancer Collaborative Group.BMJ, 311: 899–909, 1995.
37.
O’ RourkeM., GarfieldD., EllisP.: Phase II trial of taxotere (T) and navelbine (N) as first-line therapy in patients with advanced non-small cell lung cancer.Proc. Am. Soc. Clin. Oncol.,18: 519a, 1999 (abstr. 1999).
38.
PectasidesD., AspropotamitisA., HalikiaA., VisvikisA., AntoniouF., KalantaridouA., KarvounisN., BatziosS., AthanassiouA.: Combination chemotherapy with carboplatin docetaxel and gemcitabine in advanced non-small cell lung cancer: a phase II study.Eur. J. Cancer,35: 263, 1999 (suppl. 4, abstr. 1048).
39.
RaymondE., ChaneyS.G., TaammaA., CvitkovicE.: Oxaliplatin: a review of preclinical and clinical studies.Ann. Oncol., 9: 1053–1071, 1998.
40.
RowinskyE.K., HumphreyR., HammondL.A., AylesworthC., SmetzerL., HidalgoM., MorrowM., SmithL., GarnerA., SorensenJ.M., Von HoffD.D., EckhardtS.G.: Phase I and pharmacologic study of the specific matrix metalloproteinase inhibitor BAY 12-9566 on a protracted oral daily dosing schedule in patients with solid malignancies.J. Clin. Oncol., 18: 178–186, 2000.
41.
RuschV., BaselgaJ., Cordon-CardoC., OrazemJ., ZamanM., HodaS., McIntoshJ., KurieJ., DmitrovskyE.: Differential expression of the epidermal growth factors receptor and its ligands in primary non-small cell lung cancers and adjacent benign lung.Cancer Res., 53: 2379–2385, 1993.
42.
SandlerA.B., NemunaitisJ., DehnamC., von PawelJ., CormierY., GatzemeierU., MattsonK., ManegoldC., PalmerM.C., GregorA., NguyenB., NiyikizaC., EinhornL.H.: Phase III trial of gemcitabine plus cisplatin versus cispaltin alone in patients with locally advanced or metastatic non-small cell lung cancer.J. Clin. Oncol.,18: 122–130. 2000.
43.
SchillerJ.H., HarringtonD., SandlerA., BelaniC., LangerC., KrookJ., JohnsonD.H.: A randomized phase III trial of four chemotherapy regimens in advanced non-small cell lung cancer (NSCLC).Proc. Am. Soc. Clin. Oncol.,19: la, 2000 (abstr. 2).
44.
SchultzR.M., ChenV.J., BewleyJ.R., RobertsE.F., ShihC., DempseyJ.A.: Biological activity of the multitargeted antifolate, MTA (LY231514), in human cell lines with different resistance mechanisms to antifolate drugs.Sem. Oncol.,26(2 Suppl. 6): 68–73, 1999.
45.
SenanS., RamplingR., GrahamM.A., WilsonP., RobinH.Jr., EckardtN., LawsonN., McDonaldA., von RoemelingR., WorkmanP., KayeS.B.: Phase I and pharmacokinetic study of tirapazamine (SR4233) administered every three weeks.Clin. Cancer Res., 3: 31–38, 1997.
46.
ShephardP., RamlauR., MattsonK., GressotL., O’ RourkeM., VincentM., BurkesR., LevitanN., BergmanB., KraszkoP., BaezL., LynchT., RuddR., BerilleJ., KimY., CoughlinY., GrallaR.: Randomized study of taxotere (TAX) versus best supportive care (BSC) in non-small cell lung cancer patients previously treated with platinum-based chemotherapy.Proc. Am. Soc. Clin. Oncol.,18: 463a, 1999 (abstr. 1784).
47.
ShepherdF.A., ArnoldA., NevilleA., CormierY., DavisM., WierzbickiR., DanceyJ., RusthovenJ., FisherB., EisenhauerE.: Phase II study of MTA (Alimta) and cisplatin in patients with advanced non-small cell lung cancer (NSCLC).Proc. Am. Soc. Clin. Oncol.,19: 507a, 2000 (abstr. 1984).
48.
SlamonD., Leyland-JonesB., ShakS., PatonV., BajamondeA., FlemingT., EiermannW., WolterJ., BaselgaJ., NortonL.: Addition of herceptin (humanized anti-her2 antibody) to firts line chemotherapy for her2 overexpressing metastatic breast cancer (her2+/mbc) markedly increases anticancer activity: a randomized multinational controlled phase II trial.Proc. Am. Soc. Clin. Oncol.,17: 98a, 1998 (abstr. 377).
49.
von PawelJ., von RoemelingR., GatzemeierU., BoyerM., ElissonL.O., ClarkP., TalbotD., ReyA., ButlerT.W., HirshV., OlverI., BergmanB., AyoubJ., RichardsonG., DunlopD., ArcenasA., VescioR., VialletJ., TreatJ.: Tirapazamine plus cisplatin versus cisplatin in advanced non-small-cell lung cancer: a report of the international CATAPULT I study group. Cisplatin and tirapazamine in subjects with advanced previously untreated non-small cell lung tumors.J. Clin. Oncol., 18: 1351–1351, 2000.
50.
Wojtowicz-PragaS., TorriJ., JohnsonM., SteenV., MarshallJ., NessE., DicksonR., SaleM., RasmussenH.S., ChiodoT.A., HawkinsM.J.: Phase I trial of Marimastat, a novel matrix metalloproteinase inhibitor, administered orally to patients with advanced lung cancer.J. Clin. Oncol., 16: 2150–2156, 1998.
51.
WozniakA.J., CrowleyJ.J., BalcerzakS.P., WeissG.R., SpiridonidisC.H., BakerL.H., AlbainK.S., KellyK., TaylorS.A., GandaraD.R., LivingstonR.B.: Randomized trial comparing cisplatin with cisplatin plus vinorelbine in the treatment of advanced non-small cell lung cancer: a Southwest Oncology Group study.J. Clin. Oncol., 16: 2459–2465, 1998.
52.
WunderlichD., BuecheleT., ZamorynR., KegelT., MuellerL.P., GrotheyA., SchmollH.J., GraubnerM.: Biweekly docetaxel (DOC), gemcitabine (GEM) and oxaliplatin (LOHP) in pretreated patients with solid tumors. Results of a phase I study.Proc. Am. Soc. Clin. Oncol.,19: 221a, 2000 (abstr. 862).
53.
YamamotoT., IkawaS., AkiyamaT., SembaK., NomuraN., MiyajimaN., SaitoT., ToyoshimaK.: Similarity of protein encoded by human c-erb-B-2 gene to epidermal growth factor receptor.Nature, 319: 230–234, 1986.
54.
ZhuZ., WitteL.: Inhibition of tumor growth and metastasis by targeting tumor-associated angiogenesis with antagonist to the receptors of vascular endothelial growth factor.Invest. New Drugs, 17: 195–212, 1999.