The proportions of unfertilized eggs in the oviducts, showing abnormal cleavage, were examined in hamsters given single or repeated doses of 30 IU human gonadotrophic hormone for the induction of ovulation. In control animals (n = 7), 1.7% of the total ovulated eggs were morphologically abnormal unfertilized eggs showing cleavage. The proportions of unfertilized eggs that were abnormal in the groups of seven hamsters treated with one, two or three doses of the gonadotrophin were 20.4%, 19.4%, and 30.4%, respectively. The proportion of unfertilized eggs showing abnormal cleavage thus appeared to increase with repeated administrations of gonadotrophin.
KotzHLHerrmanntW: A review of the endocrine induction of human ovulation. Fertil Steril1961; 12: 375–394.
2.
ThompsonCRHansenLM: Pergonal (Menotropins): a summary of clinical experience in the induction of ovulation and pregnancy. Fertil Steril1970; 21: 844–853.
3.
O'HerlihyCPepperellRJRobinsonHP: Ultrasound timing of human chorionic gonadotropin administration in clomiphene-stimulated cycle. Obstet Gynecol1982; 59: 40–45.
4.
KanayamaKSankaiTEndoT: Appearance of unfertilized ova cleaving in the ampulla of the uterine tube after repeated ovulation inducement. Jpn J Fertil Steril1989; 34: 340–344.
5.
WardMC: A study of the estrus cycle and the breeding of the golden hamster, Cricetus auratus. Anat Rec1946; 94: 139–161.
6.
GreenwaldGS: Analysis of superovulation in the adult hamster. Endocrinology1962; 71: 378–389.
7.
CharltonHH: The fate of the unfertilized egg in the white mouse. Biol Bull1917; 33: 321–338.
8.
IshibashiI: On cleavage of the unfertilized ovum of rat. Jpn J Zootech Sci1959; 30: 212–218 (In Japanese, English abstract).
9.
IshibashiI: Cytological observations on cleavage of the unfertilized ovum of rat. Jpn J Zootech Sci1961; 32: 291–300 (In Japanese, English abstract).
