We compared the sensitivities to antibacterials of Staphylococcus aureus strains isolated from skin infections in two hospitals of different sizes. There were differences between the two hospitals in the proportions of the strains isolated that were resistant to certain drugs, and these differences may be related to the patterns of drug use at each hospital. The differences in the patterns of drug use at each hospital may be due to the types of infections encountered and/or the ages of the patients, both of which differed greatly. The proportions of resistant strains may also be related to differences in the proportions of in-patients.
NishijimaSNamuraSMitsuyaKRetrospective study of bacteria isolated from skin infections during the past 15 years (1977 – 1991) at Kansai Medical University. Jpn J Dermatol1993; 103: 1988–1991.
2.
NishijimaSNamuraSNakagawaM Sensitivity to antibacterials of Staphylococcus aureus isolated from different types of skin infections. J Int Med Res1997; 25: 1–7.
3.
KurokawaIAkamatsuHNishijimaSClinical and bacteriologic evaluation of OPC-7251 in patients with acne: a double-blind group comparison study versus cream base. J Am Acad Dermatol1991; 25: 674–691.
4.
ImadaTMiyazakiSNisidaMIn vitro and in vivo antibacterial activities of a new quinolone, OPC-17116. Antimicrob Agents Chemother1992; 36: 573–579.
5.
WakebeHImadaTYonedaHEvaluation of OPC-177116 against important pathogens that cause respiratory tract infections. Antimicrob Agents Chemother1994; 38: 2340–2345.
6.
NakanishiNYoshidaSWakebeHMechanisms of clinical resistance of fluoroquinolones inStaphylococcus aureus. Antimicrob Agents Chemother1991; 35: 2562–2567.
7.
YamaguchiKOhnoAConsiderations on MRSA infections in relation to modern chemotherapy. Nippon Rinsho1992; 50: 923–931.
8.
MatsunagaTHasegawaMRyonoKIn vitro antimicrobial activity of new quinolones against clinical isolates of MRSA. Antibiot Chemother1996; 12: 701–712
