Restricted accessResearch articleFirst published online 1995-11
Insulin Secretion Levels Necessary for Efficacy of an α-Glucosidase Inhibitor on Glucose Metabolism in Patients with Non-Insulin-Dependent Diabetes Mellitus
diabetes mellitus whose glucose metabolism was unsatisfactory, even though they were receiving appropriate dietary therapy, were treated with an α-glucosidase inhibitor (0.6 mg/day) for 12 weeks. The connecting peptide immunoreactivity value (selected as the evaluation criterion of post-prandial endogenous insulin secretion) was compared in patients with and without improved glycosylated haemoglobin levels. A significant difference was found between the connecting peptide immunoreactivity value of the group with improved glycosylated haemoglobin levels (5.0 ± 1.0 ng/ml) and that in the group without the improvement (2.7 ± 0.9 ng/ml).
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