Five patients with acromegaly and five patients with prolactinoma undergoing general anaesthesia were studied. Concentrations of plasma growth hormone in patients with acromegaly and concentrations of plasma prolactin in patients with prolactinoma were measured before anaesthesia, when 250 mg levodopa was administered orally, and after anaesthesia when dopamine was infused intravenously at a rate of 5 μg/kg-min. There was no difference in hormonal (growth hormone or prolactin) response to either treatment in the anaesthetized and the awake states. These findings indicate that the functioning of dopamine receptors in the anterior pituitary is not affected by anaesthesia.
FeridMRobertCHJr: Adenohypophyseal hormones and related substances. In: The Pharmacological Basis of Therapeutics (GuillmanAGGoodmanLSRallTW, eds). New York: MacMillan, 1985; pp 1362–1388.
2.
ImuraHKatoYYoshimotoY: The role of biogenic amines in the regulation of pituitary hormone release in man, with special reference to circadian rhythmicity. In: Biological Rhythms in Neuroendocrine Activity (KawakamiM, ed). Tokyo: Igaku Shoin, 1974; pp 140–150.
3.
BlumJWKunzPFischerJA: Parathyroid hormone response to dopamine in cattle. Am J Physiol1980; 239: 255–264.
4.
CalabroMAMacLeodRM: Binding of dopamine to bovine anterior pituitary gland membranes. Neuroendocrinology1978; 25: 32–46.
5.
KebabianJWCalneDE: Multiple receptors for dopamine. Nature1979; 277: 93–96.
6.
CreeseILeffSE: Dopamine receptors: a classification. J Clin Psychopharmacol1982; 2: 329–335.
7.
BianchineJR: Drugs for Parkinson's disease. Spasticity and acute muscle spasms. In: The Pharmacological Basis of Therapeutics (GuillmanAGGoodmanLSRallTW, eds). New York: MacMillan, 1985; pp 473–490.
8.
KeyeWRJrChangWRRJJaffeRB: Prolactin secreting pituitary adenomas in women with amenorrhea or galactorrhea. Obstet Gynecol Surv1977; 32: 727–738.
9.
LiuzziAChiodiniPGBotallaL: Inhibitory effect of l-Dopa on GH release in acromegalic patients. J Clin Endocrinol Metab1972; 35: 941–943.
10.
MimsRBSteinRBBethuneJE: The effect of a single dose of l-Dopa on pituitary hormone in acromegaly, obesity and in normal subjects. J Clin Endocrinol Metab1973; 37: 34–39.
11.
HanewKSasakiASatoS: Growth hormone inhibitory and stimulatory actions of l-Dopa in patients with acromegaly. J Clin Endocrinol Metab1987; 64: 255–260.
12.
CroninMJChungCYWilsonCB: [3H]Spiperone binding to human anterior pituitaries and pituitary adenomas secreting prolactin, growth hormone, and adrenocorticotropic hormone. J Clin Endocrinol Metab1980; 50: 387–391.
13.
MartinCR: Growth hormone and somatomedins. In: Endocrine Physiology (MartinCR, ed). New York: Oxford University Press, 1985; pp 785–812.
14.
DaughadayWH: The anterior pituitary. In: Williams Textbook of Endocrinology (WilsonJDFosterDW, eds). Philadelphia: WB Saunders, 1985; pp 568–613.
15.
EverettGMBorcherdingJW: L-DOPA: effect on concentrations of dopamine, norepinephrine, and serotonin in brains of mice. Science1970; 168: 849–850.
16.
JärnbergPOBenegtssonLEkstrandJ: Dopamine infusion in man. Plasma catecholamine levels and pharmacokinetics. Acta Anaesthesiol Scand1981; 25: 328–331.
17.
OyamaT: Influence of general anaesthesia and surgical stress on the endocrine function. In: Anesthesia and the Patient with Endocrine Disease (BrownBB, ed). Philadelphia: FA Davis, 1980; pp 173–184.
18.
OyamaTLattoPHoladayDA: Effect of isoflurane anesthesia and surgery on carbohydrate metabolism and plasma Cortisol levels in man. Can Anaesth Soc J1975; 22: 696–702.
19.
ReicerCEGeorgeJMKilmanJW: Cortisol and growth hormone response to surgical stress during morphine anesthesia. Anesth Analg1973; 52: 1003–1010.
20.
TolisGHickeyIGuydaH: Effect of morphine on serum growth hormone, Cortisol, prolactin and thyroid stimulating hormone in man. J Clin Endocrinol Metab1975; 41: 797–800.
21.
LehtinenAMHovorkaJWidholmO: Modification of aspects of the endocrine response to tracheal intubation by lignocaine, halothane and thiopentone. Br J Anaesth1984; 56: 239–246.
22.
BrandtMKehletHBinderC: Effect of epidural analgesia on the glycoregulatory endocrine response. Clin Endocrinol1976; 5: 107–114.
23.
NoelLSuhHKStoneJ: Human prolactin and growth hormone release during surgery and other conditions of stress. J Clin Endocrinol Metab1972; 35: 840–851.
24.
MurakawaTMatsukiAKudoT: Epidural anesthesia for removal of retrovesical tumor in an acromegalic patient. Agressologie1982; 23: 325–327.
25.
MorganLBarretABeswickF: Prolactin concentrations during anaesthesia. Br Med J1976; 2: 980.
26.
SebelPSBovillJGSchellenkensAPM: Hormonal responses to high-dose fentanyl anaesthesia. A study in patients undergoing cardiac surgery. Br J Anaesth1981; 53: 941–948.
27.
AdashiEYRebarRWEharaY: Impact of acute surgical stress on anterior pituitary function in female subjects. Am J Obstet Gynecol1980; 138: 609–614.
28.
LawsonDMGalaRR: Influence of anesthetics on basal, perphenazine-induced and thyrotrophin releasing hormone-induced prolactin secretion in ovariectomized, oestrogen treated rats. J Endocrinol1975; 66: 151–157.
29.
BlackardWGWaddellCC: Cholinergic blockade and growth hormone responsiveness to insulin hypoglycemia. Proc Soc Exp Biol Med1969; 131: 192–196.
30.
MurakawaTYamashitaMWakayamaS: Effect of nitroglycerin-induced hypotension on plasma human growth hormone and insulin levels. Masui1985; 34: 161–164.
31.
BarbarinoADe MarinisL: Calcium antagonists and hormone release. II. Effects of verapamil on basal, gonadotropin-releasing hormone and thyrotropin-releasing hormone-induced pituitary hormone release in normal subjects. J Clin Endocrinol Metab1980; 51: 749–753.
32.
KhoTLHarquestJWPuntR: Influence of dobutamine and dopamine on hemodynamics and plasma concentrations of noradrenalin and renin in patients with low cardiac output following acute myocardial infarction. Eur J Clin Pharmacol1980; 18: 213–217.
33.
ZaritskyALPollackMMSchaibleDH: Dopamine infusion in plasma catecholamines. Crit Care Med1984; 12: 214.
