Maternal,Umbilical,Uterine and Amniotic Prostaglandin E and F 2α Levels in Labour

Abstract

This paper confirms the important role played by prostaglandins in the induction of uterine contractions and the initiation of human labour, although the exact mechanism of action in labour remains unclear. Seventeen pregnant women at term were studied. Of these nine were in labour and the remainder underwent elective section. Prostaglandin E and F_2α levels were measured in maternal, umbilical and uterine plasma and amniotic fluid by radioimmunoassay. Levels of prostaglandin E were generally higher than prostaglandin F_2α but they were significantly lower in maternal and uterine plasma. Levels of prostaglandin F_2α were significantly higher in maternal plasma during labour. The highest levels of prostaglandin were found in amniotic fluid. Measurements indicate that the decreasing ratio of prostaglandin E/F_2α is more important in the initiation of labour than absolute levels of either prostaglandin.