A randomized, double-blind, double-dummy crossover study on 42 asthmatics was carried out to compare the single dose effects of salbutamol administered from the widely used metered dose inhaler and a breath operated system (Diskhaler®). The bronchodilator response (change in forced expiratory volume in the first second) was almost identical for the two systems. The Diskhaler® system however, since it is breath operated, obviates the need for hand–breath coordination.
