Lewis lung carcinoma was found to cause hypercalcaemia in tumour-bearing mice. 24R,25-Dihydroxyvitamin D3, a naturally occurring steric epimer, significantly prolonged the survival time of mice with Lewis lung carcinoma. It also had an analgesic effect in mice with Lewis lung carcinoma and increased the strength of bone weakened by the carcinoma which causes abnormal calcium metabolism and results in hypercalcaemia.
OrimoH: Study on the biological action of 24R,25(OH)2D3-hypocalcemic effect in rats. In: Vitamin D Chemical, Biochemical and Clinical Update (NormanAW, eds). Berlin: Walter de Gruyter, 1985; pp 296–297.
2.
PavlovitchJTCournot-WitmerGBourdeauA: Suppressive effect of 24R,25-dihydroxycholecalciferol on bone resorption induced by acute bilateral nephrectomy in rats. J Clin Invest1981; 68: 803–810.
3.
CorvolMTDumontierMFGarabedianM: Vitamin D and cartilage. II. Biological activity of 25-hydroxycholecalciferol and 24R,25- and 1,25-dihydroxycholecalciferols on cultured growth plate chondrocytes. Endocrinology1978; 102: 1269–1274.
4.
EndoHKiyokiMKawashimaK: Vitamin D3 metabolites and PTH synergistically stimulate bone formation in chick embryonic femur in vitro. Nature1980; 286: 262–264.
5.
SömjenDKayeAMBindermanI: 24R,25-Dihydroxyvitamin D stimulates creatine kinase BB activity in chick cartilage cells in culture. FEBS Lett1984; 167: 281–284.
6.
SömjenDSömjenGJWeismanY: Evidence for 24, 25-dihydroxycholecalciferol receptors in long bones of newborn rats. Biochem J1982; 204: 31–36.
7.
TsutsumiCHoshibaKMoriuchiS: Regulatory effect of calcium-regulating hormones on the synthesis and/or secretion of bone-r-carboxyglutamic acid-containing protein in chick embryonic calvaria in vitro. J Nutr Sci Vitaminol1986; 32: 157–169.
8.
MundyGRIbbotsonKJD'SouzaSM: The hypercalcaemia of cancer. N Engl J Med1984; 310: 1718–1727.
9.
GennariCChierichettiSMPioliniM: Analgesic activity of salmon and human calcitonin against cancer pain: a double-blind placebo-controlled clinical study. Curr Ther Res1985; 38: 298–308.
10.
MatsumotoTEzawaIMoritaK: Effect of vitamin D metabolites on bone metabolism in a rat model of postmenopausal osteoporosis. J Nutr Sci Vitaminol1985; 31(suppl): S61–S65.
11.
KaiserET: Synthesis of Steroids US4217297, US4354972. Synthesis of 24, 25-dihydroxycholeciferol US3351767. (US patents.)
12.
BindermanISömjenD: 24R,25-Dihydroxycholecalciferol induces the growth of chick cartilage in vitro. Endocrinology1984; 115: 430–432.
13.
SömjenDBindermanIWeismanY: The effects of 24R,25-dihydroxycholecalciferol on ornithine decarboxylase activity and on DNA synthesis in the epiphysis and diaphysis of rat bone and in the duodenum. Biochem J1983; 214: 293–298.
