The diuretic and potassium- and magnesium-conserving action of a single dose of frusemide/triamterene, F+TRI (40 mg/50 mg), and hydrochlorothiazide/amiloride, HCT+AMI (50 mg/5 mg), fixed combination preparations were compared in ten healthy adults in a randomised double-blind placebo-controlled study. Urinary volume during 24 hours was significantly higher after HCT+AMI ingestion than after F+TRI. The urine and sodium excretions caused by HCT+AMI lasted markedly longer and were smoother than the short and somewhat unpleasant effects of F+ TRI. HCT+AMI also spared potassium and magnesium relatively more effectively than F + TRI.
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References
1.
AndersonJ (1971) A comparison of the effect of hydrochlorothiazide and frusemide in treatment of hypertensive patients. Quarterly Journal of Medicine40, 541.
2.
FrohlichE D (1975) Use and abuse of diuretics. American Heart Journal89, 1.
3.
HanzeSSeyberthH (1967) Unterschungen zur Wirkung der Diuretica Furosemid, Etarcrynsäüre und Triamteren auf renale Magnesium–und calcium–ausscheidung. Klinische Wochenschrift45, 313.
4.
HollifleldJ WSlatonP E (1981) Thiazide diuretics, hypokalemia and cardiac arrhythmias. Acta medica Scandinavica (Suppl)647, 67.
5.
LearyW PReyesA J (1982) The magnesiuric effect of a single dose of hydrochlorothiazide in healthy adults. Current Therapeutic Research32, 425.
6.
LimPJacobE (1972) Magnesium deficiency in patients on long-term diuretic therapy for heart failure. British Medical Journal3, 620.
ReyesA JLearyW P (1982) The magnesiuric effect of a single dose of furosemide in healthy adults. Current Therapeutic Research32, 406.
9.
ReyesA GLearyW PAsmalA C (1981) Urine volumes and flows after oral administration of xipamide, furosemide and hydrochlorothiazide in healthy adults. Current Therapeutic Research28, 230.
10.
RyanM PRyanM FConnihanT B (1981) The effect of diuretics on lymphocyte magnesium and potassium. Acta medica Scandinavica (Suppl)647, 152.
