Thirty-nine patients suffering front arthrosis of the knee were randomly allocated to either pirprofen 400 mg b.i.d. or indomethacin 50 mg b.i.d., the treatment being double-blind. Assessments for pain and joint stiffness were made after 2 and 4 weeks. Both treatments appeared to be equally effective and induced side-effects in a limited number of patients. Similar observations were made in those patients who continued the treatment over longer periods of time.
Get full access to this article
View all access options for this article.
References
1.
ChartJJSteinetzBGStecherVJHowieN (1981) Pharmacological evaluations of pirprofen: a potent anti-inflammatory agent. Current Therapeutic Research31, 76
2.
GoebelKM (1982) Essai comparatif en double insu du pirprofène, de l'indométacine et d'un placebo dans la polyarthrite rhumatoide. La Nouvelle Presse Médicale11, 2484
3.
JajićINekoraAChadriHA (1982) Pirprofène, indométacine et placebo dans la spondylarthrite ankylosante. La Nouvelle Presse Médicale11, 2491
4.
LudersRCMaggio-CavaliereMBEggerHGumOBResnickOBartletMFGaitoMJSooALiC (1977) Disposition of pirprofen, a new anti-inflammatory drug. Clinical Pharmacology and Therapeutics21, 721
5.
MaierRWilhelmiG (1981) Influence of anti-inflammatory drugs on spontaneous osteoarthrosis in mice. A new antirheumatic-analgesic agent: pirprofen (Rengasil) Van der KorstJK Ed, >Hans Huber, Berne
6.
WilhelmiG (1978) Effect of C 21.524-Su (pirprofen) on spontaneous osteoarthrosis in the mouse. Pharmacology16, 268
