The results of this comparative study in 210 patients offer substantial evidence of the safety and efficacy of cephalexin as therapy for acute bacterial pharyngitis and tonsillitis due to group A streptococci. In addition, administration twice a day appears to be as effective as four times a day, provided the total daily dosages are equivalent and are taken for 10 days.
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References
1.
AzlmiPHCramblettHGdel RosarioAJKronfolHHaynesREHiltyMD (1972) Cephalexin: treatment of streptococcal pharyngitis. Journal of Pediatrics80, 1042
2.
DaschnerF (1977) Cephalexinspiegel im bronchialsekret bei kindern. Muenchener Medizinische Wochenschrift119, 339
3.
DisneyFAGreenJLBreeseBBTalpeyWBTobinJR (1971) Cephalexin and penicillin therapy of childhood beta-haemolytic streptococcal infections. Postgraduate Medical Journal47 (Suppl, 47
4.
GauDWHornRFHSolomonRMJohnsonPLeighDA (1972) Streptococcal tonsillitis in general practice, a comparison of cephalexin and penicillin therapy. Practitioner208, 276
5.
GoochWMStoweFRMogabgabWJ (1972) Cephalexin in beta-haemolytic streptococcal pharyngitis. Clinical Medicine79, 11
6.
GriffithRSBlackHR (1970) Cephalexin. Medical Clinics of North America54, 1229
7.
HalprinGMMcMahonSM (1973) Cephalexin concentrations in sputum during acute respiratory infections. Antimicrobial Agents and Chemotherapy3, 703
8.
LeidermanEStoweFRMogabgabWJ (1970) Cephaloglycin and cephalexin in beta-haemolytic streptococcal pharyngitis. Clinical Medicine77, 27
9.
LightRWWyleFA (1983) Serum and sputum levels of amoxicillin and cephalexin. Current Therapeutic Research33, March (in press)
10.
LundbergC (1974) Distribution of cephalexin in the sinuses. Proceedings of a meeting on cephalosporins held at the Karolinska Hospital, Stockholm, May 24–25, 1973, p. 83. Amsterdam: Excerpta Medica
11.
MatsenJMTorstensonOSiegelSEBacanerH (1974) Use of available dosage forms of cephalexin in clinical comparison with phenoxymethyl penicillin and benzathine penicillin in the treatment of streptococcal pharyngitis in children. Antimicrobial Agents and Chemotherapy6, 501
12.
RabinovitchMMacKenzieRBrazeauMMarksMI (1973) Treatment of streptococcal pharyngitis. I. Clinical evaluation. Canadian Medical Association Journal108, 1271
13.
StillermanMIsenbergHD (1971) Streptococcal pharyngitis therapy: comparison of cyclacillin, cephalexin, and potassium penicillin V. Antimicrobial Agents and Chemotherapy p. 270
14.
StillermanMIsenbergHDMoodyM (1972) Streptococcal pharyngitis therapy, comparison of cephalexin, phenoxymethyl penicillin, and ampicillin. American Journal of Diseases of Children123, 457
