A double-blind study was performed on ninety-six parturients of the Lima Maternity Hospital, Peru, with some evidence of foetal distress who were given indistinguishably piracetam or a placebo at random in order to investigate the effects of the drug on the foetus.
The conditions of the new-born babies who had received Piracetam were superior to those of the babies treated with the placebo, as evaluated with the Apgar at 1, 5 and 10 minutes after birth and on the basis of the neurological and clinical examination as from 24 hours until they were released.
In addition, the reduction of the duration of the labour in the patients treated with Piracetam as compared with the control group was obvious.
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References
1.
BaltesEGobertJG (1972) Metabolismo del Piracetam en el hombre. Administratión crónica y efecto de las dosis. UCB División Farmacéutica. Directión de Investigaciones y Desarrollo. Junio
2.
CavagnaJ (1975) Contribution à l‘étude du rythme cardiaque foetal au cours de la période d'expulsion, Thèse, Paris
3.
CornellyMHenkelETrappH (1978) Zur Pharmakokinetik von Piracetam während der Geburt. Fortschritte der Medizin96, 1881
4.
GiurgeaCMouravieff-LesuisseFLeemansR (1970) Corrélations électropharmacologiques au cours de l'anoxie oxyprive chez le lapin en respiration libre ou artificielle. Extrait de la Revue NeurologiqueMasson, Paris
5.
GiurgeaM (1972) Piracetam toxicity and reproduction studies. UCB División Farmacéutica
6.
GobertJG (1972) Genèse d'un médicament: Le Piracetam, métabolisation et recherche biochimique. Journal de Pharmacie de Belgique27, 281
7.
HonEH (1958) The electronic evaluation of the foetal heart rate: a preliminary report. American Journal of Obstetrics and Gynecology75, 1215
8.
HonEHSze-YaY (1969) Electronic evaluation of foetal heart rate. The foetal arrhythmia index. Medical Research Engineering8, 14
9.
HuamanEJMascaroSPPeredaGJ (1980) Action of Piracetam in childbirth. The Journal of International Medical Research8, 3, 232
10.
JamesLSWeisbrotIMPrinceCEHoladayDAApgarV (1958) The acid base status of human infants in relation to birth asphyxia and the onset of respiration. Journal of Paediatrics52, 379
11.
KlinkFGrobpietzchROberheuserF (1979) Zur protektiven Wirkung von Piracetam unter der Geburt. Fortschritte der Medizin97, 2163
12.
LepageFSureauCChavinieJCannonMLehouezecR (1970) The need for technical progress in the study of the foetal heart rate. Proceedings of the 2nd European Congress of Perinatal Medicine, London. Basel, Karger. p 70
13.
MannLIPrichardJWSymnesD (1970) The effect of glucose loading on the foetal response to hypoxia. American Journal of Obstetrics and Gynecology107, 610
14.
MargariaE (1970) Etude du passage du médicament UCB 6215 à travers la barrière placentaire. Rapport interne
15.
MargariaE (1972) First experimental and clinical trials of prevention and treatment of perinatal suffering with 2-pyrrolidine acetamide, Vortrag, IV. Internat. Meeting on Anaesthesia and Reanimation, Paris
16.
MargariaECostaP (1973) Observaciones experimentales en conejo y ensayo clinico con el UCB 6215 en el tratamiento de la asfixia perinatal. ‘Resuscitation’
17.
ThomasGBlackwellRJ (1975) The analysis of continuous foetal heart rate traces in the first and second stages of labour. British Journal of Obstetrics and Gynaecology82, 634
18.
Van LierdeMDe MuylderXThomasK (1979) Interpretation of foetal heart in the second stage of labour related to the Apgar score and pH of the newborn. Intl. Symposium ‘Fetal Medicine’, Venice (Italy)
19.
Van LierdeMDe MuylderXLeonardPThomasK (1980) Etude du rythme cardiaque foetal pendant l'accouchement. Essentialia17, (4, 8
20.
Van LierdeMDe MuylderXThomasK (1980) L'interprétation des anomalies du rythme cardiaque foetal. Essentialia17, (2, 6
