Histamine-induced cutaneous wheals were measured in five healthy volunteers 2, 4, 8 and 24 hours after per os administration of a single dose of clemastine 1 mg and hydroxyzine 25 mg. Clemastine produced a mean wheal suppression of 9%, 18%, 18% and 6%, while hydroxyzine produced a mean wheal suppression of 49%, 73%, 82% and 77%.
This experiment demonstrates the potent and long-lasting anti-H1 effect of hydroxyzine.
Get full access to this article
View all access options for this article.
References
1.
HarveyR PSchocketA L (1980). Journal of Allergy and Clinical Immunology65, 2, 136.
2.
LevisSPreatSBeersaertsJDaubyJBeelenLBaugnietV (1957). Archives Internationales de Pharmacodynamic109, 127.
