In order to compare the effects on gallstone dissolution of three different doses of UDCA (4, 8 and 12 mg/kg/day), a controlled trial was carried out with seventy-one patients.
The dissolution rate was higher in the group treated with the highest dose. Stone size was the major factor affecting the outcome of treatment, with a significantly higher success rate in patients with gallstones less than 10 mm than with stones greater than 10 mm.
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