15-methyl prostaglandin F2α was administered by intramuscular injection to thirty patients to terminate pregnancy in the mid-trimester. Termination was considered successful if this occurred within 24 hours and this was so in twenty-seven cases (90%). There were no serious complications. Prochlorperazine mesylate and diphenoxylate hydrochloride reduced the incidence and severity of vomiting and diarrhoea.
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References
1.
BygdemanMBeguinFToppozadaM (1972) Intrauterine administration of 15(S)-15 methyl-prostaglandin F2α for induction of abortion. Lancetii, 1336.
2.
BygdemanMBergstramS (1976) Clinical use of prostaglandins for pregnancy termination. Population Reports Series G, No. 7.
3.
KarimS M MHillierKJamesK (1971) The effects of prostaglandins E2 and F2α administered by different routes on uterine activity and the cardiovascular system in pregnant and non-pregnant women. Journal of Obstetrics & Gynaecology of the British Commonwealth78, 172.
4.
KarimS M MSharmaS D (1972) Termination of second trimester pregnancy with IS methyl analogues of prostaglandin E2 and F2α. Journal of Obstetrics and Gynaecology of the British Commonwealth79, 737.
5.
KarimS M MRatnamS S (1974) Midtrimester termination. British Medical Journal4, 161.
6.
LaurensenN HWilsonK H (1976) Termination of mid-trimester pregnancy by serial intramuscular injection of 15(S)-15-methyl-prostaglandin F2α. American Journal of Obstetrics and Gynecology124, 169.
7.
MillerA W FCalderA AMacNaughtonM C (1972) Termination of pregnancy by continuous intrauterine infusion of prostaglandins. Lancetii, 5.
8.
RobinsJMannL I (1975) Mid-trimester pregnancy termination by intramuscular injection of a 15-metbyl analogue of F2α. American Journal of Obstetrics and Gynecology123, 625.
9.
World Health Organisation Task Force (1976) Comparison of intraamniotic prostaglandin F2α and hypertonic saline for induction of second-trimester abortion. British Medical Journali, 1373.
10.
World Health Organisation Task Force (1977) Prostaglandins and abortion. I. Intramuscular administration of 15-methyl prostaglandin F2α for induction of abortion in weeks 10–20 of pregnancy. American Journal of Obstetrics and Gynecology129, 593.
